Cell surface glycoproteins of Trypanosoma cruzi: protective immunity in mice and antibody levels in human chagasic sera

Transactions of the Royal Society of Tropical Medicine and Hygiene
D Snary

Abstract

Two cell surface glycoproteins from Trypanosoma cruzi have been compared for their ability to protect mice against an acute lethal infection. One of these, a 90,000 glycoprotein found on all stages of the parasite, protected against both bloodstream and metacyclic trypomastigote challenge. A 72,000 glycoprotein found only on insect-derived stages of T. cruzi protected only against a metacyclic trypomastigote challenge. Antibody against both of these glycoproteins was present in human chagasic sera.

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Citations

Jun 1, 1984·International Journal for Parasitology·A OsunaM C Mascaro
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·F G AraujoL Tighe
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·D Snary
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Nov 13, 1984·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M T Scott, R A Neal
Jan 1, 1993·Springer Seminars in Immunopathology·L R Travassos, I C Almeida

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