PMID: 6988353Jan 1, 1980Paper

Cell survival at low oxygen tension and dose build-up in argon

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
B M CullenJ W Boag

Abstract

Mammalian cells were exposed to 250 kVp X-irradiation in air, argon and nitrogen to determine whether cells irradiated when severely hypoxic have survival curves with lower extrapolation numbers (n) than their aerobic counterparts. Cells irradiated suspended in liquid showed no significant differences between values of 'n' irrespective of the gas used, neither was the sensitivity of cells irradiated in argon any greater than that of cells irradiated in nitrogen. In contrast, cells attached to glass dishes irradiated with the medium withdrawn were apparently much more sensitive in argon than in nitrogen. It has been demonstrated that the lower survival of cells irradiated in argon could have been caused by the greater photoelectric absorption in argon compared with nitrogen. When the dosimetric discrepancy was removed either by absorption of photoelectrons in liquid or by use of high energy radiations, there was no evidence that severe hypoxia during irradiation could lead to reduced values of 'n'.

References

Jul 1, 1979·Physics in Medicine and Biology·W W Seelentag, W Panzer
May 1, 1969·Experimental Cell Research·L Révész, B Littbrand
Aug 1, 1980·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J Midander, L Révész

Citations

Dec 1, 1980·The British Journal of Radiology·D K BewleyB C Page

Related Concepts

Argon
Carcinoma, Ehrlich Tumor
Cell Survival
Cytological Techniques
Dose-Response Relationship, Radiation
Glass (Substance)
Nitrogen
Dioxygen
Roentgen Rays

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