Cell therapy for heart disease: great expectations, as yet unmet

Heart, Lung & Circulation
Christof StammRoland Hetzer

Abstract

Regenerative medicine is often touted as an achievement of the new millennium, but many approaches to improve health by stimulating the organism's own capacity for healing have existed for a long time. Some components of today's regenerative medicine, however, are indeed fundamentally new developments, and one of those is the concept of increasing the number of contractile cells in the heart to cure heart failure, either by stimulating intrinsic regeneration processes or by transplanting exogenous cells. The aim of this paper is to review the current status of some key aspects of cell therapy and obstacles to clinical translation.

References

Jun 1, 1997·The Journal of Clinical Investigation·M H SoonpaaL J Field
Mar 13, 1999·The Journal of Clinical Investigation·S MakinoS Ogawa
May 10, 2001·Journal of Molecular and Cellular Cardiology·M ZhangC E Murry
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·D OrlicP Anversa
Apr 6, 2002·Circulation Research·Michael A LaflammeCharles E Murry
Jun 1, 2002·Circulation Research·Kishore B S Pasumarthi, Loren J Field
Oct 11, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Atta BehfarMichel Pucéat
Jan 9, 2003·Lancet·Christof StammGustav Steinhoff
May 7, 2003·Circulation·Dara L KraitchmanJeff W M Bulte
Sep 25, 2003·Cell·Antonio P BeltramiPiero Anversa
Oct 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hidemasa OhMichael D Schneider
Apr 30, 2004·The Journal of Thoracic and Cardiovascular Surgery·K H GrinnemoK Le Blanc
May 26, 2004·The Journal of Biological Chemistry·Hina W ChaudhryDebra J Wolgemuth
Jun 12, 2004·The Thoracic and Cardiovascular Surgeon·C StammG Steinhoff
Oct 9, 2004·Circulation Research·Elisa MessinaAlessandro Giacomello
Nov 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Shuguang JiangWilliam H Fleming
Feb 11, 2005·Nature·Karl-Ludwig LaugwitzKenneth R Chien
Apr 27, 2005·Circulation·Michael HofmannHelmut Drexler
Aug 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Luciano C AmadoJoshua M Hare
Sep 24, 2005·Transplantation·Agnès MaurelPhilippe Menasché
Oct 26, 2005·The Annals of Thoracic Surgery·Terrence M YauRen-Ke Li
Nov 26, 2005·The Journal of Thoracic and Cardiovascular Surgery·Amit N PatelFederico Benetti
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·Michael Brehm, Bodo E Strauer
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·Warren ShermanTomasz Siminiak
May 16, 2006·Journal of the American College of Cardiology·Emmanuel MessasAlbert A Hagège
Sep 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ken-ichiro SasakiStefanie Dimmeler
Sep 23, 2006·The New England Journal of Medicine·Ketil LundeKolbjørn Forfang
Sep 23, 2006·The New England Journal of Medicine·Volker SchächingerUNKNOWN REPAIR-AMI Investigators
Sep 23, 2006·The New England Journal of Medicine·Birgit AssmusAndreas M Zeiher

❮ Previous
Next ❯

Citations

Nov 11, 2010·Human Gene Therapy·Yeong-Hoon ChoiChristof Stamm
Mar 2, 2012·Canadian Journal of Physiology and Pharmacology·Angelika Jamnig, Günter Lepperdinger
Nov 13, 2012·Expert Opinion on Drug Delivery·Todd D Johnson, Karen L Christman
Aug 6, 2013·Mayo Clinic Proceedings·Milica Radisic, Karen L Christman
Oct 16, 2010·Cardiovascular Therapeutics·Yeong-Hoon ChoiChristof Stamm
Aug 19, 2010·Journal of Cellular and Molecular Medicine·Darwin J ProckopRoxanne L Reger
Oct 26, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Masoumeh GhafarzadehAli Eatemadi
Oct 10, 2012·Cell Transplantation·Lien-Cheng HsiaoKieran Clarke
May 26, 2017·Journal of Cellular Biochemistry·Nasser Hashemi GoradelHamed Mirzaei
Oct 20, 2012·Current Opinion in Organ Transplantation·Cristina Castells-Sala, Carlos E Semino
Oct 24, 2017·JACC. Basic to Translational Science·Melissa J Hernandez, Karen L Christman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

© 2021 Meta ULC. All rights reserved