Cell Therapy for Stress Urinary Incontinence

Tissue Engineering. Part B, Reviews
Melanie L HartJan E Brinchmann

Abstract

Urinary incontinence (UI) is the involuntary loss of urine and is a common condition in middle-aged and elderly women and men. Stress urinary incontinence (SUI) is caused by leakage of urine when coughing, sneezing, laughing, lifting, and exercise, even standing leads to increased intra-abdominal pressure. Other types of UI also exist such as urge incontinence (also called overactive bladder), which is a strong and unexpected sudden urge to urinate, mixed forms of UI that result in symptoms of both urge and stress incontinence, and functional incontinence caused by reduced mobility, cognitive impairment, or neuromuscular limitations that impair mobility or dexterity. However, for many SUI patients, there is significant loss of urethral sphincter muscle due to degeneration of tissue, the strain and trauma of pregnancy and childbirth, or injury acquired during surgery. Hence, for individuals with SUI, a cell-based therapeutic approach to regenerate the sphincter muscle offers the advantage of treating the cause rather than the symptoms. We discuss current clinically relevant cell therapy approaches for regeneration of the external urethral sphincter (striated muscle), internal urethral sphincter (smooth muscle), the neuromuscular...Continue Reading

References

Jan 1, 1980·Acta Obstetricia Et Gynecologica Scandinavica·T Rud
Sep 1, 1995·Scandinavian Journal of Primary Health Care·H Sandvik, S Hunskaar
Nov 1, 1996·Obstetrics and Gynecology·K StrohbehnJ O Delancey
Sep 1, 1996·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·L Hansson
Jan 23, 1999·Biomaterials·J A RowleyD J Mooney
Apr 1, 2000·Annals of Internal Medicine·S H SmogerG H Kloecker
Oct 29, 2000·Experimental Gerontology·V RenaultV Mouly
Apr 5, 2001·Nature·D OrlicP Anversa
Feb 9, 2002·Neurourology and Urodynamics·Lars Viktrup
Jun 5, 2003·Nature Medicine·Peter Carmeliet
Sep 13, 2003·Health and Quality of Life Outcomes·Barbara Ann Shelton Broome
Sep 23, 2003·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·V A MinassianA Al-Badr
Feb 24, 2004·Gastroenterology·John O L Delancey, James A Ashton-Miller
Mar 31, 2004·BJU International·C W McGrotherUNKNOWN MRC Incontinence Study Team
Apr 13, 2004·The Journal of Urology·Selcuk Yucel, Laurence S Baskin
Apr 20, 2004·Current Topics in Developmental Biology·Chester J Koh, Anthony Atala
Apr 22, 2004·Journal of the American Society of Nephrology : JASN·Chester J Koh, Anthony Atala
May 25, 2004·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Andrea KlauserDieter zur Nedden
Jul 23, 2004·Physiological Reviews·Gary K OwensBrian R Wamhoff
Jul 23, 2004·Physiological Reviews·Karl-Erik Andersson, Anders Arner
Oct 12, 2004·Journal of Applied Physiology·Yen-Chih HuangKeith Baar
Oct 19, 2004·Experimental Gerontology·Hannes StrasserSteffen Hering
May 17, 2005·Journal of Applied Physiology·Jan P StegemannRobert M Nerem
Jul 16, 2005·Expert Opinion on Biological Therapy·Anthony Atala
Sep 6, 2005·Science·Didier MontarrasMargaret Buckingham
Oct 26, 2005·Pathologie-biologie·E NegroniV Mouly
Apr 6, 2006·Trends in Molecular Medicine·Richard I Sherwood, Amy J Wagers
Apr 11, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Mari LehtorantaRisto Santti
Apr 25, 2006·Lancet·Anthony AtalaAlan B Retik
Aug 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Larissa V RodríguezLouis J Ignarro
Nov 14, 2006·The Journal of Clinical Investigation·Jeffrey J RossCatherine M Verfaillie
Jan 9, 2007·Best Practice & Research. Clinical Obstetrics & Gynaecology·Shing-Kai Yip, Linda Cardozo
Mar 3, 2007·World Journal of Urology·Jochen WalzHartwig Huland
Apr 10, 2007·Annals of the New York Academy of Sciences·James A Ashton-Miller, John O L DeLancey
Jun 15, 2007·Tissue Engineering·Tanyarut BoontheekulDavid J Mooney
Jul 5, 2007·Abdominal Imaging·Katarzyna J Macura, Rene R Genadry

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Citations

Oct 25, 2016·The Journal of Urology·J Koudy WilliamsKarl-Erik Andersson
Oct 25, 2016·The Journal of Urology·J Koudy WilliamsKarl-Erik Andersson
Jun 28, 2018·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Pete CulmerRichard Day
Apr 30, 2020·Praxis·Florian Schmid, Daniel Eberli
Jan 23, 2019·International Urogynecology Journal·Ahmad O KhalifaAdonis K Hijaz
Jan 7, 2021·International Neurourology Journal·Florian A SchmidDaniel Eberli
Apr 6, 2021·Aging and Disease·Sandra Fuertes-Alvarez, Ander Izeta

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BETA
biopsy
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