Cell therapy for stroke: emphasis on optimizing safety and efficacy profile of endothelial progenitor cells.

Current Pharmaceutical Design
Yuji KanekoCesar V Borlongan

Abstract

Endothelial progenitor cells (EPCs) correspond to a population of cells with novel properties capable of angiogenesis and vasculogenesis, thus they are likely to display unique role in the reconstitution of the blood brain barrier (BBB) after stroke. Laboratory evidence supports safety and efficacy of cell therapy for stroke, with limited clinical trials recently initiated. This lab-to-clinic ascent of cell-based therapeutics has been aided by the establishment of consortium consisting of thought-leaders from academia, industry, National Institutes of Health (NIH) and the United States Food and Drug Administration (FDA). However, there remain unanswered questions prior to realization of large-scale application of cell transplantation in patients. This review article discusses translational challenges associated in cell therapy, emphasizing the need for optimizing both safety and efficacy profiles for advancing the clinical applications of EPC transplantation for stroke patients.

Citations

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Jun 7, 2013·Expert Opinion on Biological Therapy·Jing Zhang, Michael Chopp
Nov 18, 2014·CNS Neuroscience & Therapeutics·Mibel M PabónCesar V Borlongan
Apr 4, 2015·Tissue Barriers·Stephen F Rodrigues, D Neil Granger
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Oct 13, 2019·Experimental Biology and Medicine·Matt HeyckCesar V Borlongan
Oct 21, 2015·Translational Stroke Research·Ike Dela Peña, Cesar V Borlongan
Feb 28, 2020·Experimental and Therapeutic Medicine·Wen ZengRong Ju
Oct 3, 2017·Neural Regeneration Research·Zi-Wei ZhouJian-Ning Zhang
Jun 28, 2020·Translational Stroke Research·Wei ChenAlireza Sarkaki
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Aug 16, 2021·Brain Research Bulletin·Juhi Samal, Tatiana Segura

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