Cell therapy in the treatment of bipolar mania in an animal model: a proof of concept study

Trends in psychiatry and psychotherapy
Bruna M AscoliAdriane R Rosa

Abstract

The rationale of mesenchymal stem cells (MSCs) as a novel therapeutic approach in certain neurodegenerative diseases is based on their ability to promote neurogenesis. Hippocampal atrophy has been related to bipolar disorder (BD) in preclinical, imaging and postmortem studies. Therefore, the development of new strategies to stimulate the neurogenesis process in BD is crucial. To investigate the behavioral and neurochemical changes induced by transplantation of MSCs in a model of mania-like behavior induced by lisdexamfetamine dimesylate (LDX). Wistar rats (n=65) received one oral daily dose of LDX (10 mg/kg) or saline for 14 days. On the 8th day of treatment, the animals additionally received intrahippocampal saline or MSC (1 µL containing 25,000 cells) or lithium (47.5 mg/kg) as an internal experimental control. Two hours after the last administration, behavioral and neurochemical analyses were performed. LDX-treated rats had increased locomotor activity compared to saline-saline rats (p=0.004), and lithium reversed LDX-related hyperactive behavior (p<0.001). In contrast, the administration of MSCs did not change hyperlocomotion, indicating no effects of this treatment on LDX-treated rats (p=0.979). We did not find differences...Continue Reading

References

Mar 27, 2012·Journal of Psychiatric Research·Robert M PostFlavio Kapczinski
May 29, 2012·Bipolar Disorders·Stephen M StrakowskiJennifer D Townsend
Jan 22, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Danielle S MacêdoAndré F Carvalho
May 10, 2015·Neuroscience and Biobehavioral Reviews·F HarrisbergerS Borgwardt
May 29, 2015·International Journal of Stem Cells·Nayoun Kim, Seok-Goo Cho
Aug 8, 2015·Anais Da Academia Brasileira De Ciências·Gabriela D ColpoAdriane R Rosa
Nov 8, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ajaykumar N SharmaJoao Quevedo

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Citations

Jun 1, 2021·Journal of Psychiatric Research·Luiz K S KanazawaRoberto Andreatini

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