PMID: 22329581Feb 15, 2012Paper

Cell therapy using induced pluripotent stem cells or somatic stem cells: this is the question

Current Stem Cell Research & Therapy
Rodrigo A Somoza, Francisco J Rubio

Abstract

A lot of effort has been developed to bypass the use of embryonic stem cells (ES) in human therapies, because of several concerns and ethical issues. Some unsolved problems of using stem cells for human therapies, excluding the human embryonic origin, are: how to regulate cell plasticity and proliferation, immunological compatibility, potential adverse side-effects when stem cells are systemically administrated, and the in vivo signals to rule out a specific cell fate after transplantation. Currently, it is known that almost all tissues of an adult organism have somatic stem cells (SSC). Whereas ES are primary involved in the genesis of new tissues and organs, SSC are involved in regeneration processes, immuno-regulatory and homeostasis mechanisms. Although the differentiating potential of ES is higher than SSC, several studies suggest that some types of SSC, such as mesenchymal stem cells (MSC), can be induced epigenetically to differentiate into tissue-specific cells of different lineages. This unexpected pluripotency and the variety of sources that they come from, can make MSC-like cells suitable for the treatment of diverse pathologies and injuries. New hopes for cell therapy came from somatic/mature cells and the discovery...Continue Reading

Citations

May 20, 2014·Journal of the National Cancer Institute·Matthias DuebgenKhalid Shah
Mar 22, 2014·Journal of Pineal Research·Francesca LuchettiFrancesco Galli
Feb 19, 2015·Journal of Tissue Engineering and Regenerative Medicine·Rodrigo A SomozaCaroline Weinstein-Oppenheimer
Apr 1, 2014·Stem Cell Research·Jean-Claude StamegnaFrançois S Roman
Oct 30, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jordi Martinez-QuintanillaKhalid Shah
Dec 6, 2014·Toxicologic Pathology·Joydeep BasuMahendra Rao
Jan 19, 2018·BMC Veterinary Research·Antoine D VeronStéphane D Girard
May 28, 2019·Science and Engineering Ethics·Nishakanthi GopalanMohd Salim Mohamed
Jul 13, 2017·Stem Cells International·Stéphane D GirardFrançois Féron
Nov 27, 2019·International Journal of Molecular Sciences·Marta KotMarcin Majka
Jul 3, 2021·Tissue Engineering. Part B, Reviews·Nureddin AshammakhiEdward J Caterson

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