Cell-to-cell signaling influences the fate of prostate cancer stem cells and their potential to generate more aggressive tumors.

PloS One
Luisa SalvatoriElisa Petrangeli

Abstract

An increasing number of malignancies has been shown to be initiated and propelled by small subpopulations of cancer stem cells (CSC). However, whether tumor aggressiveness is driven by CSC and by what extent this property may be relevant within the tumor mass is still unsettled. To address this issue, we isolated a rare tumor cell population on the basis of its CD44(+)CD24(-) phenotype from the human androgen-independent prostate carcinoma cell line DU145 and established its CSC properties. The behavior of selected CSC was investigated with respect to the bulk DU145 cells. The injection of CSC in nude mice generated highly vascularized tumors infiltrating the adjacent tissues, showing high density of neuroendocrine cells and expressing low levels of E-cadherin and β-catenin as well as high levels of vimentin. On the contrary, when a comparable number of unsorted DU145 cells were injected the resulting tumors were less aggressive. To investigate the different features of tumors in vivo, the influence of differentiated tumor cells on CSC was examined in vitro by growing CSC in the absence or presence of conditioned medium from DU145 cells. CSC grown in permissive conditions differentiated into cell populations with features simil...Continue Reading

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Citations

Apr 12, 2014·Cancers·Jennifer L BishopAmina Zoubeidi
Jun 24, 2014·Critical Reviews in Oncology/hematology·Vincenza ConteducaUgo De Giorgi
Sep 30, 2014·Trends in Molecular Medicine·Rajdeep DasLuke A Selth
Jun 30, 2015·Molecular BioSystems·Antoine Buetti-DinhRan Friedman
Aug 1, 2015·Journal of Cellular Physiology·Elisa PetrangeliLuisa Salvatori
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May 3, 2015·Endocrine-related Cancer·Jennifer L BishopAmina Zoubeidi
Feb 21, 2018·Nature Reviews. Urology·Alastair H DaviesAmina Zoubeidi
Aug 2, 2017·International Journal of Molecular Sciences·Dagmara Jaworska, Ewelina Szliszka
Feb 13, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Lu HuangXiaodong Cheng
Apr 13, 2017·Frontiers in Pharmacology·Wei QinMeng Zhao
Oct 6, 2020·Frontiers in Pharmacology·Enrico LattuadaPatrizia Filetici
Aug 24, 2020·Biochemical Pharmacology·Francesca D'EsteValentina Rapozzi

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Datasets Mentioned

BETA
GSE28313

Methods Mentioned

BETA
fluorescence-activated cell sorting
PCR
FACS
Protein Assay
xenograft

Software Mentioned

Leica FW4000
Ingenuity Pathways Analysis IPA

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