Cell transformation by Herpesvirus saimiri

Journal of Cellular Physiology
A Y Tsygankov

Abstract

Herpesvirus saimiri (Saimiriine herpesvirus-2), a gamma2-herpesvirus (rhadinovirus) of non-human primates, causes T-lymphoproliferative diseases in susceptible organisms and transforms human and non-human T lymphocytes to continuous growth in vitro in the absence of stimulation. T cells transformed by H. saimiri retain many characteristics of intact T lymphocytes, such as the sensitivity to interleukin-2 and the ability to recognize the corresponding antigens. As a result, H. saimiri is widely used in immunobiology for immortalization of various difficult-to-obtain and/or -to-maintain T cells in order to obtain useful experimental models. In particular, H. saimiri-transformed human T cells are highly susceptible to infection with HIV-1 and -2. This makes them a convenient tool for propagation of poorly replicating strains of HIV, including primary clinical isolates. Therefore, the mechanisms mediating transformation of T cells by H. saimiri are of considerable interest. A single transformation-associated protein, StpA or StpB, mediates cell transformation by H. saimiri strains of group A or B, respectively. Strains of group C, which exhibit the highest oncogenic potential, have two proteins involved in transformation-StpC and T...Continue Reading

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B BiesingerB Fleckenstein
Aug 1, 1992·Journal of Virology·J C AlbrechtB Fleckenstein
Sep 1, 1992·The Journal of Experimental Medicine·H W MittrückerB Fleischer
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J U JungR C Desrosiers
Dec 1, 1991·Journal of Virology·J U Jung, R C Desrosiers
Jan 1, 1991·Advances in Cancer Research·J J Trimble, R C Desrosiers
Jul 1, 1982·Journal of Virology·R C Desrosiers, L A Falk
Dec 1, 1995·Journal of Virology·J U JungR C Desrosiers
Sep 1, 1995·The Journal of Biological Chemistry·J U JungB Biesinger
Nov 1, 1994·Molecular and Cellular Biology·J U JungR C Desrosiers
Nov 1, 1994·Virology·J U Jung, R C Desrosiers
Dec 1, 1995·Molecular and Cellular Biology·J U Jung, R C Desrosiers
Jan 12, 1996·The Journal of Biological Chemistry·N WieseB M Bröker
Jun 1, 1996·The Journal of Experimental Medicine·F FossiezS Lebecque
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·S ZalaniS Kenney
Aug 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J KennedyA Zlotnik
Nov 13, 1996·Journal of Immunological Methods·C Rodríguez-GallegoA Arnaiz-Villena
Mar 1, 1997·Clinical Immunology and Immunopathology·C E MackewiczJ A Levy
May 1, 1997·Journal of Virology·V E NavaJ M Hardwick

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Citations

Feb 22, 2008·Journal of Virology·Keith R Jerome
Jul 30, 2005·Journal of Virology·Jens-Christian AlbrechtBrigitte Biesinger
Jun 23, 2006·European Journal of Immunology·Hirotake TsukamotoYasuharu Nishimura
Jul 10, 2009·Seminars in Cell & Developmental Biology·Urs F Greber, Daniel Puntener

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