Cell turnover in apocrine metaplasia and apocrine adenosis of the breast

Annals of Diagnostic Pathology
Ghada ElayatC A Wells

Abstract

Apocrine metaplasia (APM) is a common finding in the breast of postmenopausal women and is seen in a broad spectrum of lesions ranging from microscopic cysts to invasive apocrine carcinoma. Apocrine metaplasia within sclerosing adenosis is known as apocrine adenosis (AA) and is considered a benign lesion of the breast. Apocrine metaplasia and AA have been the subject of many studies; however, little is known about the dynamics of cell turnover in these lesions. Recent studies have shown that some forms of AA may show altered degree of proliferation along with altered expression of bcl-2 and bax proteins. In the current study, we investigate further aspects of apoptosis to help understand the mechanisms of cell turnover in AA and APM. To investigate cell turnover in APM and AA, immunohistochemistry was used to study the expression of the apoptotic markers Bak, Mcl-1, Bcl-x, and Bcl-x(L) in 45 cases of APM (13 cases of nonpapillary APM, 21 cases of simple papillary APM, and 11 cases of complex papillary APM). Also, 34 cases of AA (23 cases of non-atypical AA [NAA] and 11 cases of atypical AA [AAA]) were included in the study. The expression of hTERT and the proliferation marker Ki-67 were also determined. The TdT-mediated dUTP ni...Continue Reading

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Citations

Jun 27, 2015·Expert Review of Molecular Diagnostics·Pavel GromovIrina Gromova
Jun 12, 2016·Virchows Archiv : an International Journal of Pathology·Trine TrammFattaneh A Tavassoli
May 13, 2018·Journal of Cutaneous Pathology·Ikko MutoChika Ohata
Feb 10, 2012·Expert Review of Anticancer Therapy·Renê GerhardFernando Schmitt
Mar 28, 2012·Vector Borne and Zoonotic Diseases·Marianne CarsonAnette Loeffler

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