Cell type-dependent axonal localization of translational regulators and mRNA in mouse peripheral olfactory neurons

The Journal of Comparative Neurology
Lulu I T KorsakMichael R Akins

Abstract

Local protein synthesis in mature axons may play a role in synaptic plasticity, axonal arborization, or functional diversity of the circuit. To gain insight into this question, we investigated the axonal localization of translational regulators and associated mRNAs in five parallel olfactory circuits, four in the main olfactory bulb and one in the accessory olfactory bulb. Axons in all four main olfactory bulb circuits exhibited axonal localization of Fragile X granules (FXGs), structures that comprise ribosomes, mRNA, and RNA binding proteins including Fragile X mental retardation protein (FMRP) and the related protein FXR2P. In contrast, FXGs were not seen in axons innervating the accessory olfactory bulb. Similarly, axons innervating the main olfactory bulb, but not the accessory olfactory bulb, contained the FXG-associated mRNA Omp (olfactory marker protein). This differential localization was not explained by circuit-dependent differences in expression of FXG components or Omp, suggesting that other factors must regulate their axonal transport. The specificity of this transport was highlighted by the absence from olfactory axons of the calmodulin transcript Calm1, which is highly expressed in peripheral olfactory neurons a...Continue Reading

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Citations

May 18, 2019·Operative Neurosurgery·Matthew McCoydJosé Biller
Jun 14, 2019·Frontiers in Molecular Neuroscience·Felipe BodaleoAlexia Nunez-Parra
Sep 6, 2017·Journal of Cell Science·Cynthia GomesJeffery L Twiss
Jan 16, 2021·Cell and Tissue Research·Michele DibattistaJohannes Reisert

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