Cell type-specific bidirectional regulation of the glucocorticoid-induced leucine zipper (GILZ) gene by estrogen

The Journal of Steroid Biochemistry and Molecular Biology
Sharon H TynanGeorge F Allan

Abstract

Estrogen has numerous beneficial physiological actions; however, by acting as a mitogen, it plays a significant role in the induction and maintenance of breast cancer. Although the positive effects of estrogen on gene expression are well described, negative gene regulation is not. Using microarray analysis, we identified 27 genes that were up-regulated and 20 that were down-regulated by estrogen in MCF-7 human breast cancer cells. One gene encoding GILZ (glucocorticoid-induced leucine zipper protein), a putative apoptosis-regulating transcription factor, is rapidly down-regulated by estrogen in these cells. Estrogen antagonists block the down-regulation. The region of the GILZ promoter between nucleotides -104 and -69 mediates both basal activity and estrogen-dependent down-regulation in MCF-7 cells. This region contains a functional Oct-1 binding site and a cyclic AMP response element binding protein (CREB) binding site. The same DNA region mediates up-regulation by estrogen in HeLa and HEK293 cells, indicating that cell-specific factors are involved in estrogen regulation of this gene. The estrogen receptor (ER) is present in GILZ promoter protein complexes, but it does not bind directly to the promoter itself, as the DNA-bin...Continue Reading

References

Jun 20, 1998·Experimental Cell Research·K Y ChauK L Lee
Aug 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·O W PrallR L Sutherland
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·N J McKennaB W O'Malley
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·M SabbahG Redeuilh
Feb 9, 2000·Frontiers in Neuroendocrinology·B M SchmidtM Wehling
Mar 25, 2000·Endocrine-related Cancer·S KrajewskiJ C Reed
Feb 15, 2001·Endocrine-related Cancer·R KumarL Adam
Mar 30, 2001·The Journal of Biological Chemistry·M JakackaJ L Jameson
Aug 21, 2001·Molecular Cell·S OkamuraY Nakamura
Nov 2, 2001·Breast Cancer Research and Treatment·K B LimH Huynh
Jun 1, 2002·Molecular Endocrinology·Edward K LobenhoferCynthia A Afshari

❮ Previous
Next ❯

Citations

Oct 24, 2012·Cardiovascular Toxicology·David C AguilarQin M Chen
Dec 30, 2006·Biochemical and Biophysical Research Communications·Hao ZhangQinong Ye
Mar 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Baohui ZhaoKathleen E Bethin
Jun 27, 2007·The American Journal of Pathology·Sangjun LeeD Craig Allred
Dec 18, 2007·The Journal of Biological Chemistry·Weixi ZhangXing-Ming Shi
Jul 2, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Emira Ayroldi, Carlo Riccardi
May 26, 2016·Cellular and Molecular Life Sciences : CMLS·Eva KassiAthanasios G Papavassiliou
Mar 4, 2020·Pharmacological Reviews·Vivaswath S Ayyar, William J Jusko
Apr 12, 2019·Frontiers in Pharmacology·Oxana BereshchenkoCarlo Riccardi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.