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Cell-Type-Specific CRISPR/Cas9 Delivery by Biomimetic Metal Organic Frameworks

Journal of the American Chemical Society

Jan 15, 2020

Mram AlyamiNiveen M Khashab

Abstract

Effective and cell-type specific delivery of CRISPR/Cas9 gene editing elements remains a chal-lenging open problem. Here we report the devel-opment of biomimetic cancer cell coated zeolitic imidazolate frameworks (ZIFs) for targeted and cell-specific delivery of this genome editing ma-c...read more

Mentioned in this Paper

MCF-7 Cells
Transfection
CRISPR-Cas Systems
Tumor Cells, Uncertain Whether Benign or Malignant
Protein Biosynthesis
Gene Editing
Protein Expression
Imidazole
Zeolites
Plasma Membrane
11
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Cell-Type-Specific CRISPR/Cas9 Delivery by Biomimetic Metal Organic Frameworks

Journal of the American Chemical Society

Jan 15, 2020

Mram AlyamiNiveen M Khashab

PMID: 31931564

DOI: 10.1021/jacs.9b11638

Abstract

Effective and cell-type specific delivery of CRISPR/Cas9 gene editing elements remains a chal-lenging open problem. Here we report the devel-opment of biomimetic cancer cell coated zeolitic imidazolate frameworks (ZIFs) for targeted and cell-specific delivery of this genome editing ma-c...read more

Mentioned in this Paper

MCF-7 Cells
Transfection
CRISPR-Cas Systems
Tumor Cells, Uncertain Whether Benign or Malignant
Protein Biosynthesis
Gene Editing
Protein Expression
Imidazole
Zeolites
Plasma Membrane
11

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CRISPR for Genome Editing

Genome editing technologies enable the editing of genes to create or correct mutations. Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). Here is the latest research on the use of CRISPR-Cas system in gene editing.

CRISPR (general)

Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). CRISPR-Cas system enables the editing of genes to create or correct mutations. Discover the latest research on CRISPR here.

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Endosomal Escape and Delivery of CRISPR/Cas9 Genome Editing Machinery Enabled by Nanoscale Zeolitic Imidazolate Framework

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Shahad K AlsaiariNiveen M Khashab
Current Opinion in Lipidology

In-vivo genome editing using CRISPR-Cas9 to study lipid metabolism

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Paper Details
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