Cell-type specific increases in female hamster nucleus accumbens spine density following female sexual experience

Brain Structure & Function
N A StaffendR L Meisel


Female sexual behavior is an established model of a naturally motivated behavior which is regulated by activity within the mesolimbic dopamine system. Repeated activation of the mesolimbic circuit by female sexual behavior elevates dopamine release and produces persistent postsynaptic alterations to dopamine D1 receptor signaling within the nucleus accumbens. Here we demonstrate that sexual experience in female Syrian hamsters significantly increases spine density and alters morphology selectively in D1 receptor-expressing medium spiny neurons within the nucleus accumbens core, with no corresponding change in dopamine receptor binding or protein expression. Our findings demonstrate that previous life experience with a naturally motivated behavior has the capacity to induce persistent structural alterations to the mesolimbic circuit that can increase reproductive success and are analogous to the persistent structural changes following repeated exposure to many drugs of abuse.


Jul 1, 1990·Trends in Neurosciences·M R DeLong
Jan 1, 1990·Journal of Neural Transmission. General Section·Jeffery R Wickens
Oct 1, 1989·Trends in Neurosciences·R L AlbinJ B Penney
Jun 30, 1993·Behavioural Brain Research·R L MeiselTerry E Robinson
Nov 5, 1997·Advances in Pharmacology·Wolfram Schultz
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·Ann E KelleyM R Holahan
Apr 9, 1999·Nature Neuroscience·R A McKinneyS M Thompson
Mar 29, 2001·Behavioural Brain Research·William J Jenkins, Jill B Becker
Jul 31, 2001·International Journal of Impotence Research·F Giuliano, J Allard
Jan 24, 2002·European Urology·F Giuliano, J Allard
Jul 10, 2003·Trends in Neurosciences·Haruo KasaiHiroyuki Nakahara
Nov 19, 2003·The European Journal of Neuroscience·William J Jenkins, Jill B Becker
Dec 10, 2003·Current Opinion in Neurobiology·Jeffery R WickensBrian I Hyland
Jun 11, 2004·Nature·Masanori MatsuzakiHaruo Kasai
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ko-Woon LeePaul Greengard
Sep 19, 2006·Brain Research·R L Meisel, Amanda J Mullins
Aug 15, 2008·Neuron·Larry S ZweifelRichard D Palmiter
Oct 10, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Deanna L WallaceCarlos A Bolaños-Guzmán
Mar 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hao-wei ShenP W Kalivas
Aug 14, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Susan R Sesack, Anthony A Grace
Nov 28, 2009·Progress in Neurobiology·Mark D Humphries, Tony J Prescott
Dec 17, 2009·Hormones and Behavior·K S FrohmaderLique M Coolen
Dec 18, 2009·Biological Psychiatry·Kyle K PitchersLique M Coolen
Feb 12, 2010·Cold Spring Harbor Protocols·Wen-Biao GanJeff W Lichtman
Feb 24, 2010·Frontiers in Neuroendocrinology·V L HedgesR L Meisel
Jul 14, 2010·Genes, Brain, and Behavior·Kyle K PitchersLique M Coolen
Oct 19, 2010·Brain Structure & Function·N A StaffendR L Meisel
Feb 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alice DobiVeronica A Alvarez
Feb 25, 2011·Nature Neuroscience·Peter PenzesKevin M Woolfrey
Mar 8, 2011·Biological Psychiatry·Juhyun KimJoung-Hun Kim
Apr 8, 2011·Annual Review of Neuroscience·Charles R Gerfen, D James Surmeier
Oct 18, 2011·Current Opinion in Neurobiology·Brad A GrueterRobert C Malenka
Dec 27, 2012·Current Opinion in Neurobiology·Wolfram Schultz
Jan 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Brad A GrueterRobert C Malenka
Feb 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kyle K PitchersLique M Coolen
Feb 23, 2013·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Eric J Nestler


Jun 24, 2017·Frontiers in Systems Neuroscience·Paul E Micevych, R L Meisel
Jul 5, 2019·Archives of Sexual Behavior·Wendy Verónica Herrera-MoralesLuis Núñez-Jaramillo
Dec 18, 2020·Frontiers in Behavioral Neuroscience·Johnathan M BorlandR L Meisel
Sep 18, 2018·Current Opinion in Behavioral Sciences·John MeitzenP G Mermelstein

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