DOI: 1303.0013Oct 11, 2013Paper

Cell-type-specific microarray data and the Allen atlas: quantitative analysis of brain-wide patterns of correlation and density

ArXiv
Pascal GrangePartha P. Mitra

Abstract

The Allen Atlas of the adult mouse brain is used to estimate the region-specificity of 64 cell types whose transcriptional profile in the mouse brain has been measured in microarray experiments. We systematically analyze the preliminary results presented in [arXiv:1111.6217], using the techniques implemented in the Brain Gene Expression Analysis toolbox. In particular, for each cell-type-specific sample in the study, we compute a brain-wide correlation profile to the Allen Atlas, and estimate a brain-wide density profile by solving a quadratic optimization problem at each voxel in the mouse brain. We characterize the neuroanatomical properties of the correlation and density profiles by ranking the regions of the left hemisphere delineated in the Allen Reference Atlas. We compare these rankings to prior biological knowledge of the brain region from which the cell-type-specific sample was extracted.

Related Concepts

Related Feeds

Allen Institute for Brain Science Network

The Allen Institute for Brain Science Network is a not-for-profit biomedical research organization that provides open access to multiple neuroscience tools and resources. Find the latest research from tjr Allen Institute for Brain Science Network here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.