PMID: 7013608Jan 1, 1980Paper

Cell types in long-term propagable cultures of rat liver

Annals of the New York Academy of Sciences
J W Grisham

Abstract

Under the conditions of this experiment, propagable hepatic epithelial cells in long-term culture were derived from a small, nonparenchymal precursor cell present in the liver in vivo. Progeny of the nonparenchymal precursor cell weakly expressed some hepatocyte-like properties in culture. Hepatocytes were not clonogenic under the conditions of this experiment. Propagable hepatic epithelial cells in long-term culture probably originate from hepatic stem cells in vivo. Terminal biliary ductular cells are facultative stem cells for hepatocytes.

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Citations

May 1, 1991·Journal of Cellular Physiology·H C Bisgaard, S S Thorgeirsson
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