Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells.

Cell
Yulia ShwartzYa-Chieh Hsu

Abstract

Piloerection (goosebumps) requires concerted actions of the hair follicle, the arrector pili muscle (APM), and the sympathetic nerve, providing a model to study interactions across epithelium, mesenchyme, and nerves. Here, we show that APMs and sympathetic nerves form a dual-component niche to modulate hair follicle stem cell (HFSC) activity. Sympathetic nerves form synapse-like structures with HFSCs and regulate HFSCs through norepinephrine, whereas APMs maintain sympathetic innervation to HFSCs. Without norepinephrine signaling, HFSCs enter deep quiescence by down-regulating the cell cycle and metabolism while up-regulating quiescence regulators Foxp1 and Fgf18. During development, HFSC progeny secretes Sonic Hedgehog (SHH) to direct the formation of this APM-sympathetic nerve niche, which in turn controls hair follicle regeneration in adults. Our results reveal a reciprocal interdependence between a regenerative tissue and its niche at different stages and demonstrate sympathetic nerves can modulate stem cells through synapse-like connections and neurotransmitters to couple tissue production with demands.

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Citations

Dec 6, 2020·Experimental Dermatology·Seon A LeeTudorita Tumbar
Dec 29, 2020·Frontiers in Cell and Developmental Biology·Patrycja DaszczukKrzysztof Kobielak
Dec 2, 2020·The Journal of Investigative Dermatology·Patrick-Simon Welz
Mar 9, 2021·Frontiers in Cell and Developmental Biology·Hans I-Chen HarnCheng-Ming Chuong
Apr 2, 2021·Experimental Dermatology·Ya-Chieh Hsu, Michael Rendl
Oct 3, 2020·Cell Stem Cell·Elaine Fuchs, Helen M Blau
Apr 22, 2021·The EMBO Journal·Kefei Nina Li, Tudorita Tumbar
Feb 17, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Madelyn R LorenzErica L Scheller
Oct 23, 2020·Current Opinion in Cell Biology·Gabriella Rice, Panteleimon Rompolas
Aug 3, 2021·Frontiers in Physiology·Hongyi DuanLijian Shao
Jul 20, 2021·The Journal of Investigative Dermatology·Matilde MirandaWilliam E Lowry
Sep 4, 2021·Cell Stem Cell·Emily Scott-SolomonYa-Chieh Hsu
Oct 3, 2021·Nature Reviews. Neuroscience·Emily Scott-SolomonRejji Kuruvilla

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