Cell viability modulation through changes of Ca(2+)-dependent signalling pathways

Progress in Biophysics and Molecular Biology
Karolina Wójcik-PiotrowiczPiotr Thor

Abstract

The aim of the study was to determine the correlations between intracellular calcium ion level and a cell's ability to survive. The intracellular concentration of Ca(2+) ions, maintained through different mechanisms, plays an important role in signalling in cells. The deregulation of these mechanisms by various cell stressors (e.g. cytotoxic agents) can disturb Ca(2+) homeostasis and influence Ca(2+)-dependent signalling pathways in the cell. Perturbations of intracellular electrochemical equilibrium may lead to changes in cell function or even to cell death. According to some experimental results, one of the cell stressors may be exposure to magnetic fields (MF). Because of the wide distribution of MF sources in our environment, magnetic fields have recently been intensively examined in relation to the occurrence of cancer. Nevertheless, two questions still remain unanswered: Is the influence of MF on cells positive or negative, and what mechanism(s) underlie the effects of MF action on cells? Most studies focus on the influence of MF on Ca(2+) ion fluxes as calcium ions play the role of intracellular second messengers, triggering many signalling cascades. Physical models assuming the mechanisms generating the disturbance of i...Continue Reading

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Citations

Oct 21, 2016·The European Journal of Neuroscience·Alice C Wyse-JacksonThomas G Cotter
Jan 19, 2018·Scientific Reports·Behnam Hajipour VerdomMehrdad Behmanesh
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Jun 15, 2021·Environmental Research·Piotr PiszczekJolanta Kaszuba-Zwoińska

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