Cell Volume-Activated and Volume-Correlated Anion Channels in Mammalian Cells: Their Biophysical, Molecular, and Pharmacological Properties

Pharmacological Reviews
Yasunobu OkadaRavshan Z Sabirov

Abstract

There are a number of mammalian anion channel types associated with cell volume changes. These channel types are classified into two groups: volume-activated anion channels (VAACs) and volume-correlated anion channels (VCACs). VAACs can be directly activated by cell swelling and include the volume-sensitive outwardly rectifying anion channel (VSOR), which is also called the volume-regulated anion channel; the maxi-anion channel (MAC or Maxi-Cl); and the voltage-gated anion channel, chloride channel (ClC)-2. VCACs can be facultatively implicated in, although not directly activated by, cell volume changes and include the cAMP-activated cystic fibrosis transmembrane conductance regulator (CFTR) anion channel, the Ca2+-activated Cl- channel (CaCC), and the acid-sensitive (or acid-stimulated) outwardly rectifying anion channel. This article describes the phenotypical properties and activation mechanisms of both groups of anion channels, including accumulating pieces of information on the basis of recent molecular understanding. To that end, this review also highlights the molecular identities of both anion channel groups; in addition to the molecular identities of ClC-2 and CFTR, those of CaCC, VSOR, and Maxi-Cl were recently identi...Continue Reading

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Citations

Apr 25, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Jun ChengYan Yang
Jun 4, 2019·International Journal of Molecular Sciences·Tianbao Liu, Tobias Stauber
Oct 20, 2019·Pharmacological Reports : PR·Sarvinoz I RustamovaRavshan Z Sabirov
Aug 23, 2019·International Journal of Oncology·Atsushi ShiozakiEigo Otsuji
Oct 31, 2020·Clinical and Experimental Pharmacology & Physiology·Nargiza M ChorievaRavshan Z Sabirov
Jan 1, 2021·Biochemical and Biophysical Research Communications·Satoshi YamadaHisao Yamamura
Jan 30, 2021·Chemical Research in Toxicology·Andrea Boente-JuncalLuis M Botana
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Takahiro ShimizuHideki Sakai
Feb 1, 2020·Pharmacological Reports : PR·Sarvinoz I RustamovaRavshan Z Sabirov
Feb 23, 2021·Pulmonary Circulation·Guogu LiuAiguo Dai
May 22, 2021·Communications Biology·Tomohiro NumataYasunobu Okada
Jun 18, 2021·Journal of Cardiovascular Pharmacology and Therapeutics·Dun NiuZhizhong Xie
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Markus RitterHubert H Kerschbaum
Aug 8, 2021·International Journal of Molecular Sciences·Nadezhda BarvitenkoAntonella Pantaleo
Oct 14, 2021·American Journal of Physiology. Cell Physiology·Alan S Verkman, Luis J V Galietta

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