Cell volume and the metabolic actions of insulin

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
R Zhande, R W Brownsey

Abstract

Insulin increases the volume of isolated hepatocytes and cells in perfused livers, but effects of the hormone on the volume of fat or muscle cells have not been demonstrated. Exogenous amino acids may stimulate swelling of liver cells and induce insulin-like effects on hepatic protein metabolism; however, swelling of liver cells can be induced by some treatment that do not induce insulin-like metabolic responses. Exogenous amino acids also influence protein metabolism of fat and muscle cells, but no relationship with cell volume has been established and no corresponding effects on metabolism of carbohydrates or lipids have been observed. Three families of mitogen-activated protein kinases are activated after changes in extracellular osmolarity but they appear to play little or no role in the metabolic actions of insulin. Direct evidence against a metabolic role for the extracellular signal-regulated kinases ERK-1 and ERK-2 is discussed. The c-Jun N-terminal kinases (also called stress-activated protein kinases) and the mammalian homologs of the yeast Hog protein kinase are strongly activated by environmental stresses associated with catabolic metabolism. We conclude that cell volume and protein metabolism may be correlated in l...Continue Reading

References

Feb 1, 1977·The Journal of Physiology·T Clausen, P G Kohn
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J KatzP A Wals
Oct 1, 1992·The Biochemical Journal·B StollD Häussinger
Mar 15, 1992·The Biochemical Journal·M al-HaboriL Agius
Aug 1, 1991·The American Journal of Physiology·E WeilY Gutman
Nov 15, 1991·The Biochemical Journal·S vom DahlD Häussinger
Jun 1, 1991·Pflügers Archiv : European journal of physiology·C HallbruckerD Häussinger
Sep 15, 1991·The Biochemical Journal·S Vom DahlD Häussinger
Jul 15, 1991·European Journal of Biochemistry·C HallbruckerD Häussinger
Jan 1, 1990·Annual Review of Physiology·S Grinstein, J K Foskett
Jun 1, 1990·Biological Chemistry Hoppe-Seyler·M WettsteinD Häussinger
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L B Ray, T W Sturgill
Jan 1, 1986·Annual Review of Physiology·W H Moolenaar
Oct 10, 1986·Science·E Rozengurt
Sep 12, 1988·FEBS Letters·P A MacLennanM J Rennie
Sep 1, 1974·The Biochemical Journal·D M SalmonD A Hems
Jun 15, 1984·European Journal of Biochemistry·H J Balks, K Jungermann
Feb 1, 1981·Biophysical Journal·R D Moore
Oct 1, 1994·The Journal of Clinical Investigation·G S HotamisligilB M Spiegelman
Jan 1, 1995·International Review of Cytology·E K Hoffmann, P B Dunham
Feb 1, 1995·European Journal of Biochemistry·R M Denton, J M Tavaré
Oct 1, 1994·The American Journal of Physiology·E Weil-MaslanskyS Sasson
May 1, 1994·Biochemical Society Transactions·L AgiusT H Thomas
Jan 1, 1994·Annual Review of Physiology·S R KimballL S Jefferson
May 12, 1994·Nature·J M KyriakisJ R Woodgett
Jan 1, 1994·Annual Review of Medicine·K J Tracey, A Cerami
Nov 1, 1993·The American Journal of Physiology·J C Parker
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G PagèsJ Pouysségur
Feb 1, 1996·The Biochemical Journal·D Häussinger

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Citations

Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·A J Meijer, H P Sauerwein
May 18, 1999·The American Journal of Physiology·W C O'Neill

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