Cell wall and secreted proteins of Candida albicans: identification, function, and expression.

Microbiology and Molecular Biology Reviews : MMBR
W L ChaffinJ P Martínez

Abstract

The cell wall is essential to nearly every aspect of the biology and pathogenicity of Candida albicans. Although it was initially considered an almost inert cellular structure that protected the protoplast against osmotic offense, more recent studies have demonstrated that it is a dynamic organelle. The major components of the cell wall are glucan and chitin, which are associated with structural rigidity, and mannoproteins. The protein component, including both mannoprotein and nonmannoproteins, comprises some 40 or more moieties. Wall proteins may differ in their expression, secretion, or topological location within the wall structure. Proteins may be modified by glycosylation (primarily addition of mannose residues), phosphorylation, and ubiquitination. Among the secreted enzymes are those that are postulated to have substrates within the cell wall and those that find substrates in the extracellular environment. Cell wall proteins have been implicated in adhesion to host tissues and ligands. Fibrinogen, complement fragments, and several extracellular matrix components are among the host proteins bound by cell wall proteins. Proteins related to the hsp70 and hsp90 families of conserved stress proteins and some glycolytic enzym...Continue Reading

References

Oct 1, 1975·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S De NollinM Borgers
Dec 1, 1978·Journal of Clinical Microbiology·W Rudek
Mar 1, 1978·Microbiological Reviews·E D Weinberg
Dec 1, 1976·The Journal of Investigative Dermatology·T L Ray, K D Wuepper
Jan 1, 1976·Advances in Microbial Physiology·C Ballou
Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·G GoldsteinE A Boyse
Aug 7, 1992·Science·C CenciarelliA M Weissman
May 1, 1992·The Journal of Burn Care & Rehabilitation·A N NeelyI A Holder
Jul 1, 1992·European Journal of Biochemistry·S BozziniP Speziale
Aug 11, 1992·Infection and Immunity·J E EdwardsR A Calderone
Aug 1, 1992·Current Opinion in Immunology·D B Young
May 1, 1992·European Journal of Epidemiology·E SegalD Dayan
Nov 1, 1992·Infection and Immunity·F D Tosh, L J Douglas
May 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C FailleD Poulain
Dec 1, 1992·Journal of Bacteriology·R J WrightP A Sullivan
Sep 1, 1992·Immunology Today·R Matthews, J Burnie
Jan 1, 1992·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·S Goyal, G K Khuller
Jan 1, 1992·Critical Reviews in Microbiology·B R OttoD M MacLaren
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C ShoemakerD Harn
Apr 1, 1992·Clinical Microbiology Reviews·D R Soll
Jun 1, 1992·The Journal of Experimental Medicine·M A MoorsD M Mosser
Mar 1, 1992·Journal of General Microbiology·M HommaK Tanaka
Jan 1, 1991·Annual Review of Cell Biology·D Finley, V Chau
Oct 1, 1991·Journal of General Microbiology·A BanerjeeA Datta
Nov 22, 1991·Proceedings. Biological Sciences·R P HartlandP A Sullivan

❮ Previous
Next ❯

Citations

Jan 11, 2000·Molecular and Cellular Biology·D DavisA P Mitchell
Aug 12, 2000·Journal of Bacteriology·Y C Chang, L A Penoyer
May 24, 2001·Journal of Bacteriology·D R SingletonK C Hazen
Aug 15, 2001·Antimicrobial Agents and Chemotherapy·G RamageJ L López-Ribot
May 23, 2002·Antimicrobial Agents and Chemotherapy·Letizia AngiolellaAntonio Cassone
Oct 18, 2002·Antimicrobial Agents and Chemotherapy·Peter A Suci, Bonnie J Tyler
Oct 18, 2002·Antimicrobial Agents and Chemotherapy·Stefano P BachmannJosé L López-Ribot
Nov 19, 2002·Antimicrobial Agents and Chemotherapy·Françoise DromerDaniel Poulain
Sep 6, 2008·Microbiology and Molecular Biology Reviews : MMBR·W LaJean Chaffin
Jan 9, 2008·Antimicrobial Agents and Chemotherapy·Letizia AngiolellaAnna Teresa Palamara
Jan 20, 2011·Infection and Immunity·Dmitry A SolovievWilliam A Fonzi
Feb 2, 2011·PLoS Pathogens·Sonja I GringhuisTeunis B H Geijtenbeek
Jun 13, 2001·Infection and Immunity·A Y JongK S Kim
Jul 4, 2001·Trends in Microbiology·R A Calderone, W A Fonzi
Aug 10, 2001·Microbiology·M WeigF A Mühlschlegel
Jul 31, 2007·Future Microbiology·Steffen Rupp
Aug 22, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·A Beauvais, J P Latgé
Dec 21, 2004·FEMS Immunology and Medical Microbiology·André Luis Souza Dos Santos, Rosangela Maria de Araújo Soares
Feb 26, 2010·World Journal of Biological Chemistry·André Luis Souza Dos Santos
May 6, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C S-Y LimP P Chong
Mar 18, 2021·Acta Biomaterialia·Giuseppe PezzottiIchiro Nishimura
Dec 17, 2015·Journal of Nanobiotechnology·Humberto H LaraMiguel Jose-Yacaman
Dec 29, 2004·Journal of Drug Targeting·M Alam KhanO Mohammad
Mar 4, 2008·Gerodontology·Magna Carvalho de Menezes ThieleEdvaldo Antonio Ribeiro Rosa
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Angela BacciLuigina Romani
Jan 25, 2005·Infection and Immunity·Donatella PietrellaAnna Vecchiarelli
May 19, 2011·Molecular Microbiology·Dagmara S DonohueRonnie G Willaert
Jan 28, 2005·Antimicrobial Agents and Chemotherapy·Ying-Ying CaoYuan-Ying Jiang
Jun 30, 2011·Critical Reviews in Biotechnology·Sven CuyversChristophe M Courtin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.