Cell/Bacteria-Based Bioactive Materials for Cancer Immune Modulation and Precision Therapy.

Advanced Materials
Hong PanLintao Cai

Abstract

Numerous clinical trials for cancer precision medicine research are limited due to the drug resistance, side effects, and low efficacy. Unsatisfactory outcomes are often caused by complex physiologic barriers and abnormal immune events in tumors, such as tumor target alterations and immunosuppression. Cell/bacteria-derived materials with unique bioactive properties have emerged as attractive tools for personalized therapy in cancer. Naturally derived bioactive materials, such as cell and bacterial therapeutic agents with native tropism or good biocompatibility, can precisely target tumors and effectively modulate immune microenvironments to inhibit tumors. Here, the recent advances in the development of cell/bacteria-based bioactive materials for immune modulation and precision therapy in cancer are summarized. Cell/bacterial constituents, including cell membranes, bacterial vesicles, and other active substances have inherited their unique targeting properties and antitumor capabilities. Strategies for engineering living cell/bacteria to overcome complex biological barriers and immunosuppression to promote antitumor efficacy are also summarized. Moreover, past and ongoing trials involving personalized bioactive materials and pr...Continue Reading

References

May 15, 1972·International Journal of Cancer. Journal International Du Cancer·W J Halliday, S Miller
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·W B WhitmanW J Wiebe
Jun 17, 2000·Science·P A OldenborgF P Lindberg
Nov 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·L H DangB Vogelstein
Aug 1, 2002·Journal of the American Chemical Society·Reiko SadamotoShin-Ichiro Nishimura
Mar 5, 2003·Annual Review of Immunology·Drew Pardoll
Jul 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yunping LuoRong Xiang
Dec 14, 2004·Nature·M Claire Horner-DevineBrendan J M Bohannan
Jan 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ming ZhaoRobert M Hoffman
Sep 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hiroshi Noguchi, Gerhard Gompper
Apr 4, 2006·Cancer Biology & Therapy·P K BhatnagarM R Suresh
Nov 18, 2006·Cell·Gaorav P Gupta, Joan Massagué
Nov 13, 2007·Advanced Drug Delivery Reviews·F PierigèM Magnani
Feb 12, 2008·Nature Reviews. Microbiology·Yong-Mei Zhang, Charles O Rock
Jul 26, 2008·Cancer Gene Therapy·M LoefflerJ C Reed
Nov 20, 2010·Chemical Communications : Chem Comm·Samuel SanchezOliver G Schmidt
Feb 26, 2011·Expert Opinion on Drug Delivery·Elena V BatrakovaAlexander V Kabanov
Mar 26, 2011·Science·Christine L Chaffer, Robert A Weinberg
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Che-Ming J HuLiangfang Zhang
Jul 2, 2011·Nature Reviews. Drug Discovery·Jin-Wook YooSamir Mitragotri
Dec 24, 2011·Nature·Ira MellmanGlenn Dranoff
Jan 12, 2012·ACS Nano·Alexander A SolovevOliver G Schmidt
Feb 9, 2012·Current Opinion in Immunology·Mark P ChaoRavindra Majeti
Apr 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Wilber Quispe-TintayaClaudia Gravekamp
May 29, 2013·Advanced Materials·Weiwei GaoLiangfang Zhang
Aug 8, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sheng-Nan JiangJung-Joon Min
Sep 21, 2013·Nature Immunology·Thomas F GajewskiYang-Xin Fu
Apr 22, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Aaron C Anselmo, Samir Mitragotri
Nov 22, 2014·ACS Nano·Zhiguang WuJoseph Wang
Jan 24, 2015·Nano Letters·Weiwei GaoLiangfang Zhang
May 29, 2015·Science Translational Medicine·Tal DaninoSangeeta N Bhatia
Sep 9, 2015·Nature Biotechnology·Elvin BlancoMauro Ferrari
Sep 17, 2015·Nature·Che-Ming J HuLiangfang Zhang
Sep 30, 2015·Advanced Materials·Quanyin HuZhen Gu
Nov 20, 2015·Biomaterials·Siddarth ChandrasekaranMichael R King
Dec 2, 2015·Advanced Drug Delivery Reviews·Yoshihiro KomoharaMotohiro Takeya
Dec 24, 2015·Nature Reviews. Cancer·Luo Gu, David J Mooney
Feb 26, 2016·Biotechnology Journal·Leo van der PolPeter van der Ley
Oct 31, 2016·Advanced Drug Delivery Reviews·Carlos H VillaVladimir Muzykantov

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Citations

Oct 5, 2021·Chemical Society Reviews·Qi-Wen ChenXian-Zheng Zhang

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