CellBlockistry: Chemistry and art of cell-block making - A detailed review of various historical options with recent advances

CytoJournal
Vinod B Shidham

Abstract

Cell-blocks are paraffin-embedded versions of cytology specimens comparable to the formalin-fixed paraffin-embedded (FFPE) tissue from surgical pathology specimens. They allow various elective ancillary studies on a variety of specimens with enhanced cytopathologic interpretation, including opportunity to perform molecular tests. However, different dictionaries and internet search engines primarily project "cellblock" and "cell block" definition in relation to prisons. Most of the top searches lead to information related to "prison cells" followed by a few cytopathology-related searches. Due to this in the current review, it is recommended that the word for cytopathology purposes should be hyphenated and spelled as "cell-block." Cell-blocks have been increasingly indicated on most cytology specimens. Its role is growing further with the ongoing addition of new immunohistochemistry (IHC) markers with technical advances including multicolor IHC and the SCIP (subtractive coordinate immunoreactivity pattern) approach. In addition, it is an important source of tissue for many ancillary studies even as archived material retrospectively at later stage of management if the cell-blocks are improved qualitatively and quantitatively. Beca...Continue Reading

References

Jan 1, 1986·Annals of the New York Academy of Sciences·K A MuirheadP K Horan
Jan 1, 1987·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·M K Sidawy, S G Silverberg
May 1, 1982·Journal of Clinical Pathology·G Bussolati
Jul 6, 2000·Cytopathology : Official Journal of the British Society for Clinical Cytology·M B KulkarniA M Borges
Jan 10, 2002·Diagnostic Cytopathology·Patricia A FetschAndrea Abati
Dec 6, 2002·The American Journal of Pathology·Mythily SrinivasanScott Jewell
Jan 5, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marco WachtelBeat W Schäfer
Jun 11, 2008·Acta Cytologica·Prateek BhatiaRaje Nijhawan
Jul 23, 2009·Journal of Visualized Experiments : JoVE·George M Varsegi, Vinod Shidham
Jul 31, 2010·Journal of Clinical Pathology·Frederick Mayall, Ann Darlington
Nov 19, 2010·Journal of Visualized Experiments : JoVE·Vinod B ShidhamParameswaran Hari
Feb 4, 2011·Journal of Clinical Pathology·Frederick G Mayall, Ian Wood
Jun 12, 2012·Journal of Clinical Pathology·Frederick George Mayall
Aug 13, 2014·Cytopathology : Official Journal of the British Society for Clinical Cytology·D JainV K Iyer
Apr 23, 2016·Cancer Cytopathology·Ronald BalassanianMartha B Pitman
Aug 25, 2016·Archives of Pathology & Laboratory Medicine·Anjali Saqi
Feb 1, 2017·Cancer Cytopathology·Kristin A La FortuneHarvey M Cramer
May 23, 2017·Journal of the American Society of Cytopathology : JASC·Fresia ParejaMarcia Edelweiss
Jun 4, 2017·Scientific Reports·Jaya TalrejaLobelia Samavati
Nov 3, 2017·Archives of Pathology & Laboratory Medicine·Natasha RekhtmanOscar Lin
Mar 17, 2018·Archives of Pathology & Laboratory Medicine·Deepali Jain, Sinchita Roy-Chowdhuri
Aug 29, 2018·Cytopathology : Official Journal of the British Society for Clinical Cytology·Aruna Nambirajan, Deepali Jain

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Citations

Mar 13, 2020·Cancer Cytopathology·Momin T Siddiqui
Oct 4, 2020·American Journal of Clinical Pathology·Maximiliano Ramia de CapAthena L Chen
Oct 31, 2020·Diagnostic Cytopathology·Hamza N GokozanClaire W Michael
Aug 14, 2020·Cytopathology : Official Journal of the British Society for Clinical Cytology·Lisi YuanKathryn S Dyhdalo
Jan 28, 2021·CytoJournal·Vinod B Shidham
Feb 19, 2021·CytoJournal·Vinod B Shidham, Lester J Layfield
Apr 22, 2021·CytoJournal·Swati Satturwar, Liron Pantanowitz
Jul 6, 2021·CytoJournal·Ahmed AlrajjalAli Gabali
Oct 11, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Savitri Krishnamurthy, Kechen Ban

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Methods Mentioned

BETA
biopsies
biopsy
flow cytometry

Software Mentioned

Nano
HistoGel
Cellient
JoVE
NextGen
Micro

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