Cells and extracellular matrix interplay in cardiac valve disease: because age matters

Basic Research in Cardiology
Cristiano SpadaccioAlberto Rainer

Abstract

Cardiovascular aging is a physiological process affecting all components of the heart. Despite the interest and experimental effort lavished on aging of cardiac cells, increasing evidence is pointing at the pivotal role of extracellular matrix (ECM) in cardiac aging. Structural and molecular changes in ECM composition during aging are at the root of significant functional modifications at the level of cardiac valve apparatus. Indeed, calcification or myxomatous degeneration of cardiac valves and their functional impairment can all be explained in light of age-related ECM alterations and the reciprocal interplay between altered ECM and cellular elements populating the leaflet, namely valvular interstitial cells and valvular endothelial cells, is additionally affecting valve function with striking reflexes on the clinical scenario. The initial experimental findings on this argument are underlining the need for a more comprehensive understanding on the biological mechanisms underlying ECM aging and remodeling as potentially constituting a pharmacological therapeutic target or a basis to improve existing prosthetic devices and treatment options. Given the lack of systematic knowledge on this topic, this review will focus on the ECM...Continue Reading

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Citations

Feb 15, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Marek KaweckiAleksandra Kasperczyk
May 19, 2018·American Journal of Physiology. Heart and Circulatory Physiology·David A LiemJiaWei Han
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Dec 20, 2020·Journal of Cardiovascular Development and Disease·Karthik M KodigepalliJoy Lincoln
Feb 4, 2021·JACC. Basic to Translational Science·Rihab BoucharebDjamel Lebeche
Feb 16, 2021·Frontiers in Cell and Developmental Biology·Xudong ZhuZhenyu Ju
Mar 10, 2018·Current Opinion in Physiology·Amanda J LeBlancMonika George
May 4, 2021·BioMed Research International·Francesco NappiChristophe Acar
Jun 25, 2021·Journal of Molecular and Cellular Cardiology·Cierra J WalkerLeslie A Leinwand
Jun 18, 2021·BioMed Research International·Adelaide IervolinoFrancesco Nappi
Aug 3, 2021·Journal of Molecular and Cellular Cardiology·Ashley J ScottKristyn S Masters

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