Cells at the center of Dictyostelium aggregates become spores

Developmental Biology
H J HuangC Pears

Abstract

The cellular slime mold Dictyostelium discoideum undergoes a developmental life cycle on starvation to generate a fruiting body consisting of a mass of spores supported on a stalk of dead, vacuolated cells. The choice between alternative cell fates is influenced by a variety of factors including cell cycle position at the onset of starvation. We present evidence to suggest that the cell cycle position influences cell fate by determining the position of cells in the early aggregate. The existence of a strain which cannot initiate development on its own but which can respond to signals generated by nonmutant cells has allowed us to investigate the eventual cell fate of the initiating cells which are, by definition, at the center of the early aggregate. Cells which have a propensity to become prespore cells show an increased efficiency in initiating development of this strain. Labeling the initiating cells by the expression of green fluorescent protein reveals that these cells become spores. The higher levels of expression of genes characteristic of early development in cells with a prespore tendency are consistent with the earlier expression of the components of relay in prespore cells.

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Citations

Feb 25, 2010·Microbial Ecology·Santosh SatheVidyanand Nanjundiah
May 28, 2010·Biology Letters·Jennie J Kuzdzal-FickJoan E Strassmann
May 19, 2011·Development, Growth & Differentiation·Yasuo Maeda
May 19, 2011·Development, Growth & Differentiation·Joan E Strassmann, David C Queller
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Joan E Strassmann, David C Queller
Aug 19, 2008·The American Naturalist·Richard Ellis HudsonDenis Roze
Jun 16, 2004·Developmental Biology·Hsiu-Hsu Sophia LinCatherine Pears
Jan 26, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Vidyanand Nanjundiah, Santosh Sathe
Mar 23, 2021·Frontiers in Cell and Developmental Biology·Ranjani Dhakshinamoorthy, Shashi P Singh
Jan 22, 2000·Developmental Biology·J M Brown, R A Firtel
Dec 11, 1999·Biochimica Et Biophysica Acta·H Huang, C Pears
Aug 15, 2002·Current Biology : CB·Joseph A BrzostowskiAlan R Kimmel
Dec 21, 2010·Trends in Genetics : TIG·Si I Li, Michael D Purugganan

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