Cells infected with herpes simplex virus induce human monocyte-macrophages to produce interferon

Immunobiology
T L StanwickA J Nahmias

Abstract

Human monocyte-macrophages (MO) produced interferon when incubated with human fibroblast, Vero cell, or rabbit kidney cell cultures infected with herpes simplex virus (HSV). Induction of MO interferon required a 12-hour incubation with the HSV-infected cultures. The interferon produced biologically resembled human leukocyte-derived rather than human fibroblasts-derived interferon.

References

Feb 1, 1977·Cellular Immunology·P S MorahanE R Kern
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·L Rasmussen, T C Merigan
Sep 1, 1974·The Journal of Experimental Medicine·D L Lodmell, A L Notkins
Jul 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·L A GlasgowJ K Petralli

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