Cell's intrinsic biophysical properties play a role in the systematic decrease in time-locking ability of central auditory neurons.

Neuroscience
S YangA S Feng

Abstract

Studies in the vertebrates have shown that the time-locking ability of central auditory neurons decreases progressively along the ascending auditory pathway. This decrease is presumably attributed to a progressive reduction in the fidelity of synaptic transmission and an increase in the influence of synaptic inhibition along the cascade. The extent to which neurons' intrinsic biophysical properties contribute to the change in time-locking ability is unclear. We carried out whole-cell patch clamp recordings from the auditory thalamus of leopard frogs and compared their biophysical properties and time-locking abilities (determined by cell's responses to depolarizing pulse trains applied intracellularly) with those of lower auditory brainstem neurons. We found that frog thalamic neurons were homogeneous, exhibiting uniformly sustained, regular firing patterns, but not having low-threshold transient Ca2+ current which mammal thalamic neurons generally possess. Furthermore, intrinsic biophysical properties of the thalamic neurons are such that the time-locking ability of these neurons was very poor. The homogeneity of thalamic auditory neurons is in contrast to the heterogeneity of lower auditory brainstem neurons, with different ph...Continue Reading

References

Jul 1, 1992·Hearing Research·G Langner
Apr 22, 1991·The Journal of Comparative Neurology·A S Feng, W Y Lin
Jan 20, 1983·The Journal of Comparative Neurology·T J Neary, R G Northcutt
Oct 13, 1995·Science·R V ShannonM Ekelid
Apr 1, 1999·Annual Review of Physiology·L O Trussell
Apr 1, 1999·Annual Review of Physiology·D Oertel
Jan 1, 2000·The Journal of the Acoustical Society of America·D C FitzpatrickR Batra
Apr 27, 2000·Trends in Neurosciences·B Hutcheon, Y Yarom
Sep 11, 2001·Journal of the Association for Research in Otolaryngology : JARO·A M SimmonsC E Garabedian
Sep 11, 2002·Brain, Behavior and Evolution·C E Carr, D Soares
Mar 27, 2004·Physiological Reviews·P X JorisA Rees
Mar 24, 2006·Journal of Neurophysiology·Rodolfo R Llinás, Mircea Steriade
Aug 10, 2007·Journal of Neurophysiology·Sungchil Yang, Albert S Feng
Dec 7, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christofer J EdwardsGary J Rose

❮ Previous
Next ❯

Citations

Dec 15, 2012·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Andrea Megela Simmons

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.