PMID: 4890861Jun 1, 1969Paper

Cells involved in the immune response. VII. The demonstration, using allotypic markers, of antibody formation by irradiation-resistant cells of irradiated rabbits injected with normal allogeneic bone marrow cells and sheep erythrocytes

The Journal of Experimental Medicine
M Richter, N I Abdou

Abstract

Bone marrow cells obtained from rabbits of one allotype were injected into irradiated rabbits of a different allotype. The recipients were also injected with sheep red blood cells, and their spleen cells were tested for plaque-forming capacity 7 days later. Spleen cells of all recipients gave large numbers of plaques as did spleen cells incubated with antiserum, directed toward donor allotype. However, incubation of the recipient spleen cells with antiserum directed toward recipient allotype completely suppressed plaque formation. These results demonstrate that antibody-formation in irradiated recipients of transferred lymphoid cells is a property of the recipient animal and that the antibody-forming cell is relatively irradiation-resistant. It was also demonstrated that only viable normal bone marrow cells are capable of transferring antibody-forming capacity to irradiated recipient rabbits. Neither sonicates nor heat-killed preparations of normal rabbit bone marrow cells possessed this capacity.

References

Nov 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·E WeilerE Breuninger-Peck
Aug 1, 1967·The Journal of Experimental Medicine·W A RobinsonE Diener
Jan 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·G F Mitchell, J F Miller
Jun 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·A A GottliebP Doty
May 1, 1968·The Journal of Experimental Medicine·M Virolainen
May 1, 1968·The Journal of Experimental Medicine·D D McGregor
Sep 1, 1968·The Journal of Experimental Medicine·R van Furth, Z A Cohn
Aug 1, 1966·The Journal of Experimental Medicine·A Volkman
May 1, 1957·Proceedings of the Society for Experimental Biology and Medicine·T N HARRISM B FARBER
Dec 5, 1959·Nature·S DUBISKIA KELUS
Aug 25, 1962·Nature·S DRAYJ OUDIN
Apr 26, 1963·Science·N K Jerne, A A Nordin

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Citations

Aug 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·N I Abdou, M Richter
Jan 1, 1970·The Journal of Experimental Medicine·S K Singhal, H Wigzell
Nov 1, 1970·The Journal of Experimental Medicine·W W Bullock, M B Rittenberg
Jan 1, 1974·The Journal of Experimental Medicine·M Taniguchi, T Tada
Dec 10, 2013·Acta Cirúrgica Brasileira·Rafael Panisi de Campos MeirellesLydia Masako Ferreira
Feb 1, 1975·Cellular Immunology·N Donnelly, D H Sussdorf

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