PMID: 4893095Jul 1, 1969Paper

Cells involved in the immune response. X. The transfer of antibody-forming capacity to irradiated rabbits by antigen-reactive cells isolated from normal allogeneic rabbit bone marrow after passage through antigen-sensitized glass bead columns

The Journal of Experimental Medicine
N I Abdou, M Richter

Abstract

The antigen-reactive cells in normal rabbit bone marrow could be isolated from a suspension of marrow cells by passage of the cells through an antigen-sensitized glass bead column. The cells which passed through the column were deficient in antigen-reactive cells directed to the antigen used to sensitize the glass beads, whereas the cells eluted from the column could transfer antibody-forming capacity to irradiated recipients only with respect to the specific sensitizing antigen. Separation of the bone marrow antigen-reactive cells could not be achieved by passage of the cells through nonsensitized glass bead columns or in the presence of excess free antigen in the column. Cells which were retained by, and later eluted from, the antigen-sensitized glass bead columns were mostly small mononuclear cells, whereas cells which passed through the columns were morphologically similar to the original unfractionated bone marrow cell suspension. The data indicate the presence of an antibody or antibody-like structure, with defined immunological specificity, on the surface of the normal bone marrow antigen-reactive cell.

References

Feb 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·E Merler, C A Janeway
Sep 1, 1968·The Journal of Experimental Medicine·B F Argyris
Jul 1, 1966·Transplantation·A J DaviesP C Koller
Nov 18, 1967·Nature·J F Miller, G F Mitchell

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Citations

Nov 1, 1978·Mechanisms of Ageing and Development·V K GhantaM H Durant
Aug 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·N I Abdou, M Richter
Jan 1, 1970·The Journal of Experimental Medicine·S K Singhal, H Wigzell
Aug 1, 1972·The Journal of Experimental Medicine·D T Golan, Y Borel
Jan 1, 1970·Transplantation Reviews·H Wigzell
Jan 1, 1970·Scandinavian Journal of Haematology·H H HeitmannU Schnappauf
Aug 1, 1974·European Journal of Immunology·W HaasA Szenberg
Nov 7, 1980·Journal of Chromatography·S K Sharma, P P Mahendroo

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