Cells of origin and tumor-initiating cells for nonmelanoma skin cancers.

Cancer Letters
Khanh ThieuDavid M Owens

Abstract

The epidermis of the skin is a multilayered stratified epithelium whose primary function is to provide a barrier against our external environment. As a result, cells in the epidermis are subject to constant assault from environmental pathogens, many of which can cause deleterious mutations. However, most of these mutations do not lead to skin cancer. One explanation is that most genetic hits are sustained by mature or transit cells with limited proliferative capacity and only stem cells that acquire genetic alterations have the potential to propagate a frank tumor. In this mini-review we will discuss recent studies that provide some of the first genetic evidence to support a stem cell origin for a number of skin cancer types.

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Citations

Dec 24, 2019·Frontiers in Genetics·Joanna PyczekHeidi Hahn
May 29, 2020·Cellular and Molecular Life Sciences : CMLS·Minna PiipponenVeli-Matti Kähäri
May 7, 2019·Cells·Emanuel Rognoni, Gernot Walko
May 22, 2020·JCI Insight·Hélène ChoquetEric Jorgenson

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