Cells that Express Brain-Derived Neurotrophic Factor mRNA in the Developing Postnatal Rat Brain

The European Journal of Neuroscience
W J FriedmanHåkan Persson

Abstract

Brain-derived neurotrophic factor (BDNF) is a member of a family of related neurotrophic proteins which includes nerve growth factor (NGF) and hippocampus-derived neurotrophic factor/neurotrophin-3 (NT-3). To obtain information regarding possible roles for BDNF during postnatal brain development, we have examined the temporal and spatial expression of this trophic factor using in situ hybridization. In specific neocortical regions BDNF mRNA-expressing cells were seen at 2 weeks of age and thereafter. One particular neuronal cell type strikingly labelled was the inverted pyramidal cell population in the deep layers of parietotemporal cortex. In pyriform and cingulate cortices, BDNF mRNA was detected at postnatal day 1 and 1 week of age, respectively, with increasing levels during ontogeny. Several forebrain regions, including the thalamic anterior paraventricular nucleus, hypothalamic ventromedial nucleus as well as the preoptic area, contained moderate levels of BDNF mRNA throughout development. BDNF mRNA was detected transiently in several brainstem structures, notably in the substantia nigra and interpeduncular nucleus. Expression of this trophic factor in hippocampus was relatively low in the early neonatal brain, but attain...Continue Reading

References

Aug 1, 1992·Journal of Neuroscience Research·T Ebendal
Aug 10, 2004·Cell and Tissue Research·Kerstin Krieglstein
Nov 20, 1992·Brain Research. Developmental Brain Research·G W HuntleyP J Isackson
Mar 19, 1993·Brain Research. Developmental Brain Research·T RingstedtH Persson
May 26, 1995·Brain Research. Developmental Brain Research·A A SchoupsI B Black
May 1, 1994·Trends in Neurosciences·R M LindsayP S DiStefano
May 1, 1994·Trends in Neurosciences·E G Jones
Oct 1, 1994·Brain Research. Molecular Brain Research·H M Chao, B S McEwen
Jul 1, 1994·Neurochemistry International·T Timmusk, M Metsis
Dec 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D LindholmE Castrén
Jan 1, 1994·Progress in Growth Factor Research·K Unsicker
Dec 23, 1996·Brain Research. Developmental Brain Research·J ZhouG M Stern
May 20, 1997·Brain Research. Developmental Brain Research·J ZhouG M Stern
Jul 1, 1997·Brain Research. Molecular Brain Research·K N SalimH M Chao

Citations

Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K L AllendoerferC J Shatz
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P ErnforsH Persson
Mar 23, 1990·Science·P C MaisonpierreG D Yancopoulos
Jun 1, 1989·Neuron·Y A Barde
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C R BuckM V Chao
Sep 4, 1987·Science·R Levi-Montalcini
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S R WhittemoreH Persson
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Aviv, P Leder
Jun 1, 1965·The Journal of Comparative Neurology·J Altman, G D Das
Oct 1, 1980·Physiological Reviews·H Thoenen, Y A Barde

Related Concepts

Cortex Bone Disorders
Adrenal Cortex Diseases
Entire Brainstem
Structure of Paraventricular Nucleus
Preoptic Areas
Recombinant Brain-Derived Growth Factors
Brain-Derived Neurotrophic Factor Measurement
Neurotrophic factor
Biologic Development
Substantia Nigra Structure

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.