PMID: 1214022Jan 1, 1975Paper

Cellular activity in the dermis surrounding the hair bulb in alopecia areata

Journal of Cutaneous Pathology
G E Pierard, M de la Brassinne

Abstract

The metabolic activity of the cells in the connective tissue surrounding the hair bulb has been studied by radioautography in alopecia areata and in normal scalp, using in vitro incorporation of tritiated thymidine, uridine, histidine, leucine and proline. In alopecia areata, the hair bulbs are blocked in the anagen IV stage and DNA, RNA and protein synthesis are restrained. Cells in the papilla, as well as the cellular infiltrate, display a very low rate of metabolic activity. During regrowth in alopecia areata, the activity of endothelial cells is increased in the papillary and peribulbar layers before DNA, RNA and protein synthesis are restored in the epithelial cells of the hair bulb. The dermal and epithelial labelling patterns eventually reach levels comparable to those observed in an induced anagen IV state of a normal scalp. It is concluded that the progression from anagen IV to a further stage represents a critical period in the growth of hair that would closely depend upon an adequate metabolic function of the connective tissue. It is impaired in alopecia areata.

References

Jan 1, 1975·Journal of Cutaneous Pathology·G E Pierard, M de la Brassinne
Aug 1, 1973·The British Journal of Dermatology·J M Lachapelle, M De la Brassinne
Apr 1, 1968·The British Journal of Dermatology·J EckertF J Ebling
Nov 1, 1968·The British Journal of Dermatology·P PopchristovE Obreshkova
Sep 1, 1957·A.M.A. Archives of Dermatology·A W KOPF, N ORENTREICH
Nov 1, 1958·The Journal of Investigative Dermatology·E J VAN SCOTT, T M EKEL

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Citations

Jul 1, 1994·Journal of Dermatological Science·A J McDonagh, A G Messenger
Jun 17, 2006·The American Journal of Dermatopathology·Klaus Sellheyer, Wilma F Bergfeld
May 1, 1978·International Journal of Dermatology·D A Weigand
Mar 30, 2011·Journal of Cell Science·Ryan R DriskellFiona M Watt
Jan 1, 1976·Journal of Cutaneous Pathology·M F de la Brassinne, G E Pierard
Oct 1, 1984·Clinics in Dermatology·E Panconesi
Feb 1, 1984·The British Journal of Dermatology·B B MajewskiE L Rhodes
Jul 1, 1982·International Journal of Dermatology·G Ioannides
Dec 1, 1980·Journal of Cutaneous Pathology·C Franchimont, G E Pierard
Oct 1, 1996·Dermatologic Clinics·A J McDonagh, A G Messenger
Dec 3, 2014·Actas dermo-sifiliográficas·C BernárdezL Requena
May 23, 2008·International Journal of Cosmetic Science·C Piérard-FranchimontG E Piérard
Feb 21, 2004·Skin Pharmacology and Physiology·G E PiérardUNKNOWN EEMCO group (European Expert Group on Efficacy Measurement of Cosmetics and other Topical Products)
Dec 1, 1990·The British Journal of Dermatology·A J McDonaghA G Messenger

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