Cellular adhesion molecules and their relationship with measures of obesity and metabolic syndrome in a multiethnic population

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Michelle A Miller, F P Cappuccio

Abstract

The relationships between adhesion molecules and measures of obesity and metabolic syndrome in different ethnic populations are unclear. Our aim was to study the association between body mass index (BMI), waist-hip ratio (WHR) and the parameters of the metabolic syndrome with four different adhesion molecules, adjusting for potential confounders, in men and women from different ethnic origins. Soluble plasma adhesion molecules (sP-selectin, sE-selectin, intracellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) were measured in 261 white (120 women), 188 African origin (99 women) and 215 South Asian (99 women) individuals living in South London. All were free from coronary heart disease (CHD), stroke and other cardiovascular disease (CVD), diabetes, drug therapy for hypertension or high lipids, hormone replacement therapy or oral contraceptive pill. sE-selectin levels were positively and significantly associated with both BMI (P < 0.001) and WHR (P < 0.001). There were no major interactions with either sex or ethnicity. The strength of the association between sE-selectin and WHR was not affected by multiple adjustment for age, sex, ethnicity smoking, blood pressure, serum lipids and insulin (P <...Continue Reading

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Citations

May 11, 2007·The British Journal of Nutrition·Jennifer B KeoghPeter M Clifton
Jan 19, 2008·The Journal of Clinical Investigation·Satoshi NishimuraSeiryo Sugiura
Nov 2, 2012·Nutrition & Metabolism·Caroline Isoppo de SouzaMarcia Silveira Graudenz
Oct 19, 2011·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Michelle A Miller
Jan 26, 2016·Metabolic Syndrome and Related Disorders·Harry Robberecht, Nina Hermans
Jan 3, 2016·Clinical Biochemistry·Ishwarlal JialalSridevi Devaraj
Dec 8, 2007·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Tzung-Dau WangSsu-Yuan Chen
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