Cellular adhesion molecules in urologic malignancies

American Journal of Clinical Pathology
M B CohenJ S Ross

Abstract

Cell adhesion molecules (CAMs) are important in cell-cell interaction and interactions between cells and components of the extracellular matrix. CAMs have been associated with invasion and metastasis in a wide variety of human malignancies, including tumors of the genitourinary tract. Cadherins are transmembrane glycoproteins that bind cells by homophilic, homotypic interactions. Loss of expression of E-cadherin has been associated with dedifferentiation, invasion, and metastasis in prostate cancer and transitional cell neoplasia of the urinary bladder. CD44, a family of transmembrane glycoproteins principally involved in cell-extracellular matrix interactions, also has been associated with invasion and metastasis in urologic malignancies. Through alternative splicing, a variety of CD44 isoforms can be expressed that can undergo extensive posttranslational modification. CD44 variants have been associated with metastasis in a variety of human malignancies, particularly in the gastrointestinal system. Although loss of expression of CD44 standard form has been associated with aggressive prostate gland and bladder cancers, no specific isoform has been associated with metastasis of these neoplasms. Integrins are transmembrane glycop...Continue Reading

Citations

Oct 21, 2004·Cancer·David G BostwickBarry Timms
Jan 30, 2007·Breast Cancer Research and Treatment·Gerwin HellerSabine Zöchbauer-Müller
Aug 27, 2017·Pathology Oncology Research : POR·Sayra DilmacGamze Tanriover
Feb 13, 2003·The Journal of Pathology·Michael D SlaterJulian A Barden
Dec 29, 2005·International Journal of Cancer. Journal International Du Cancer·Venkata SabbisettiGirish Shah
Jul 19, 2013·Nature Reviews. Cancer·Muhammad H Zaman
May 1, 2017·Expert Review of Endocrinology & Metabolism·Aydin SavKalman Kovacs
Dec 15, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Shih-Lun ChangYu-Ching Wei
Jan 17, 2002·The Journal of Urology·H A ArafatS Chacko
Apr 1, 2015·Molecular Medicine Reports·Changjun CaoPucha Jiang
Jan 10, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Young Ju JeongJin Gu Bong
Mar 28, 2002·Advances in Anatomic Pathology·Jeffrey S RossBhaskar V S Kallakury
Nov 6, 2009·Nature Reviews. Urology·Karen J Aitken, Darius J Bägli
Jan 21, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bing PanLemin Zheng
Feb 14, 2002·Critical Reviews in Oncology/hematology·Malcolm D MasonWen G Jiang
Jun 30, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Haris KokotasGeorge Kitsos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer
M StreitE D Kreuser
International Journal of Oral and Maxillofacial Surgery
A J Lyons, J Jones
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
S M Albelda, C A Buck
© 2022 Meta ULC. All rights reserved