PMID: 6982473Sep 1, 1982Paper

Cellular analysis of specificity of antibodies and of delayed type hypersensitivity responses toward some structurally related synthetic antigens: boosting is determined by specificity of T cells

Proceedings of the National Academy of Sciences of the United States of America
B Parhami-SerenM Sela

Abstract

The crossreactivity between the random synthetic polypeptide antigen poly(Tyr,Glu)-poly(DLAla)--poly(Lys) [(T,G)-A--L] and its ordered-sequence analogs (Tyr-Tyr-Glu-Glu)-poly(DLAla)--poly(Lys) [(T-T-G-G)-A--L] and (Tyr-Glu-Tyr-Glu)-poly(DLAla)--poly(Lys) [(T-G-T-G)-A--L] at the level of humoral and cellular responses was studied. For delayed type hypersensitivity responses, (T,G)-A--L-activated T cells could be challenged with the homologous antigen as well as with the ordered analogs. T cells activated by (T-T-G-G)-A--L could be challenged with either the homologous antigen or with (T,G)-A--L but not with (T-G-T-G)-A--L. Similarly, no cross stimulation was observed between (T-G-T-G)-A--L-activated cells and (T-T-G-G)-A--L, whereas (T,G)-A--L could challenge the latter cells to mediate significant responses. Similar but not identical cross reactions were observed when primed spleen cells or lymph nodes were transferred to irradiated recipients that were boosted for the production of antibodies. In contrast to observations at the level of cellular responses, (T-G-T-G)-A--L-primed spleen or lymph node cells could not be boosted with (T,G)-A--L for the production of detectable amounts of antibodies, although boosting with the homo...Continue Reading

References

Jan 1, 1975·International Archives of Allergy and Applied Immunology·M A VadasA Whitelaw
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M SchwartzM Sela
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·M SchwartzM Sela
Jan 21, 1972·Science·B Benacerraf, H O McDevitt
Mar 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·R Hunter
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg

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