PMID: 9660366Jul 11, 1998Paper

Cellular and anatomical reservoirs of HIV-1 in patients receiving potent antiretroviral combination therapy

JAMA : the Journal of the American Medical Association
L K Schrager, M P D'Souza

Abstract

The eradication of human immunodeficiency virus 1 (HIV-1) from infected persons is the ultimate goal of HIV therapeutic interventions. Great strides have been made in developing potent antiretroviral regimens that greatly suppress HIV-1 replication. Despite these therapeutic advances, major obstacles remain to eradicating HIV-1. Reservoirs of HIV-1 have been identified that represent major impediments to eradication. Conceptually, there are 2 types of sanctuaries for HIV-1, cellular and anatomical. Cellular sanctuaries may include latent CD4+ T cells containing integrated HIV-1 provirus; macrophages, which may express HIV-1 for prolonged periods; and follicular dendritic cells, which may hold infectious HIV-1 on their surfaces for indeterminate lengths of time. The key anatomical reservoir for HIV-1 appears to be the central nervous system. An understanding of the nature of HIV within these reservoirs is critical to devising strategies to hasten viral eradication.

Citations

Mar 25, 2014·Journal of Nanobiotechnology·Jimma Likisa LenjisaGizaw Dabessa Satessa
Nov 1, 2001·Proceedings of the National Academy of Sciences of the United States of America·P BlancouR Cheynier
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·T W Chun, A S Fauci
Jun 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·S D FrostA J Brown
Apr 17, 2014·Viruses·Angela Battistini, Marco Sgarbanti
Sep 6, 2000·Proceedings. Biological Sciences·R A ArnaoutD Wodarz
Oct 9, 2002·Journal of Virology·Una O'DohertyMichael H Malim
Jan 5, 2006·Cerebrospinal Fluid Research·Christy AnthonypillaiSarah A Thomas
Jan 12, 2010·AIDS Research and Human Retroviruses·Antonio ValentinGeorge N Pavlakis
Oct 20, 2010·International Journal of Nanomedicine·Rama Mallipeddi, Lisa Cencia Rohan
May 10, 2011·PLoS Computational Biology·Jessica M Conway, Daniel Coombs
Oct 19, 2011·PLoS Pathogens·Gretja SchnellRonald Swanstrom
Feb 14, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Hans S L M NottetCharles A B Boucher
Feb 15, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·A LafeuilladeE Delbeke
Mar 29, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·A FraternaleM Magnani
Mar 29, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·O LambotteJ F Delfraissy
Aug 24, 2010·The Journal of Antimicrobial Chemotherapy·Christopher J DestacheMichael A Belshan

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