Cellular and humoral immune responses during intrathoracic paracoccidioidomycosis in BALB/c mice

Comparative Immunology, Microbiology and Infectious Diseases
Caio C S AlvesAna P Ferreira

Abstract

Paracoccidioidomycosis is a chronic infection that primarily affects the lungs. Here we investigated cellular and humoral immune responses after intrathoracic Paracoccidioidesbrasiliensis infection in BALB/c mice. P. brasiliensis-colony-forming units (CFUs), fungal DNA and granulomas in lungs increased progressively, peaking at day 90 postinfection (p.i.). IFN-gamma production was highest on day 15 p.i., declining thereafter. The kinetics of the NO production was similar to that described for IFN-gamma. In contrast, IL-10 increased from day 45 p.i. reaching a peak at day 90. Levels of serum IgG1 were higher than IgG2a between days 30 and 90 p.i. 30% of mice died by day 90 p.i. These data indicate that infection with P. brasiliensis by the intrathoracic route shows high IFN-gamma and NO production at day 15 p.i., unable to control multiplication of fungi, which appears to be associated with a progressive increase in IL-10 and in the number and complexity of granulomas.

References

Jan 1, 1990·British Journal of Pharmacology·M G HenriquesB B Vargaftig
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Aug 12, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·V L Calich, S S Kashino
Aug 28, 1998·Research in Immunology·V L CalichE Burger
Oct 26, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G Benard, A J Duarte
Feb 6, 2002·Trends in Microbiology·M Ines Borges-WalmsleyAdrian R Walmsley
Jul 10, 2004·Antioxidants & Redox Signaling·Salvatore CuzzocreaDaniela Salvemini
Jan 24, 2007·Microbiology and Immunology·Diego Luís CostaAngela Maria Victoriano de Campos Soares
Apr 21, 2007·Microbiology and Immunology·Cilmery Suemi KurokawaMaria Terezinha S Peraçoli
Sep 28, 2007·European Journal of Immunology·Teresa ZelanteLuigina Romani

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Citations

Oct 24, 2012·Mycoses·Mariana Àlvares de Abreu e SilvaKaren Cherubini
Nov 20, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mariana À de Abreu E SilvaKaren Cherubini

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