Cellular and ionic mechanisms underlying erythromycin-induced long QT intervals and torsade de pointes

Journal of the American College of Cardiology
C AntzelevitchG X Yan

Abstract

This study sought to elucidate the cellular and ionic basts for erythromycin-induced long QT syndrome. Erythromycin is known to produce long QTU intervals on the electrocardiogram (ECG) and to be associated with the development of torsade de pointes (TdP). The mechanisms responsible for the adverse effects of this widely used antibiotic are not well defined. The present study used microelectrode and whole-cell patch-clamp techniques to assess the effects of erythromycin on epicardial, endocardial and M cells in transmural strips, arterially perfused wedges and single myocytes isolated from the canine left ventricle. In isolated strips, erythromycin (10 to 100 micrograms/ml) produced a much more pronounced prolongation of the action potential duration (APD) in M cells than in endocardial and epicardial cells, resulting in the development of a large dispersion of repolarization across the ventricular wall at slow stimulation rates. Erythromycin (50 to 100 micrograms/ml) induced early after depolarizations (EADs) in cells in the M (20%) but not epicardial or endocardial regions in transmural strips of ventricular free wall. Erythromycin (100 micrograms/ml) also caused APD prolongation and a transmural dispersion of repolarization,...Continue Reading

References

Mar 16, 1979·Pflügers Archiv : European journal of physiology·D AttwellC Ojeda
Jun 1, 1992·Pacing and Clinical Electrophysiology : PACE·M A Habbab, N el-Sherif
Feb 1, 1992·Pflügers Archiv : European journal of physiology·M C Sanguinetti, N K Jurkiewicz
Jan 1, 1987·Pflügers Archiv : European journal of physiology·E Carmeliet
Jan 1, 1989·Pflügers Archiv : European journal of physiology·F Scamps, E Carmeliet
Sep 1, 1988·Progress in Cardiovascular Diseases·W M JackmanR Lazzara
Sep 15, 1986·The American Journal of Cardiology·D GuelonJ P Haberer
Sep 1, 1980·British Journal of Clinical Pharmacology·K L AustinP J McDonald
Dec 28, 1995·The New England Journal of Medicine·W Cates, M S Cohen
Aug 10, 1995·The New England Journal of Medicine·W H Franklin, R W Hickey
Mar 1, 1995·Journal of Cardiovascular Electrophysiology·S C VerduynH J Wellens
Nov 1, 1994·Journal of Cardiovascular Electrophysiology·B SzaboR Lazzara
Jun 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M W BrandrissS S Barold
Aug 1, 1993·Circulation·P J SchwartzR S Crampton
Mar 24, 1993·JAMA : the Journal of the American Medical Association·R L WoosleyR A Gillis
May 1, 1992·Trends in Cardiovascular Medicine·A J Moss, J L Robinson

❮ Previous
Next ❯

Citations

Nov 30, 2000·Current Treatment Options in Cardiovascular Medicine·S Viskin
Aug 4, 2004·Progress in Biophysics and Molecular Biology·William BainsCat White
Jul 1, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Eman Abu-GharbiehFabrizio De Ponti
Dec 13, 2003·Journal of Pharmacological and Toxicological Methods·R L HamlinT Arnold
Jun 14, 2002·European Journal of Pharmacology·Pascale GluaisMonique Adamantidis
Aug 7, 2002·European Journal of Pharmacology·András Farkas, Susan J Coker
Apr 16, 1998·Journal of Electrocardiology·C AntzelevitchS Sicouri
May 7, 2003·Progress in Biophysics and Molecular Biology·Peter TaggartPanny Kallis
Mar 15, 2000·Journal of the American College of Cardiology·W Shimizu, C Antzelevitch
Dec 14, 1999·Alimentary Pharmacology & Therapeutics·M ToniniF Crema
Apr 12, 2001·European Journal of Clinical Investigation·R WolkP Kulakowski
Oct 7, 2000·Clinical and Experimental Pharmacology & Physiology·H J Witchel, J C Hancox
Feb 27, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·K YamamotoM Yamamoto
Dec 22, 2000·Current Opinion in Cardiology·C Antzelevitch
Jan 16, 2002·Current Opinion in Cardiology·Charles Antzelevitch, Wataru Shimizu
Dec 24, 1998·Journal of Clinical Psychopharmacology·M D DriciD A Flockhart
Mar 27, 2003·Journal of Cardiovascular Pharmacology·Pascale GluaisMonique Adamantidis
Mar 19, 2002·American Journal of Therapeutics·Robert R Fenichel
Aug 3, 2011·Cardiology in Review·Daniel B Kramer, Peter J Zimetbaum
May 30, 1998·Pacing and Clinical Electrophysiology : PACE·D M Roden
Jan 5, 2001·Pacing and Clinical Electrophysiology : PACE·A LubinskiG Swiatecka
Nov 15, 2002·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Wataru Shimizu
Feb 7, 2007·Acta Physiologica·M J KilleenC L-H Huang
Nov 30, 2007·Acta Physiologica·M J KilleenC L-H Huang
Sep 23, 2009·Circulation·Satish R RajDan M Roden
Dec 7, 2013·British Journal of Anaesthesia·C StaikouE Stavroulakis

❮ Previous
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