PMID: 18209887Jan 23, 2008Paper

Cellular and molecular abnormalities of a macronodular adrenal hyperplasia causing beta-blocker-sensitive Cushing's syndrome

Arquivos brasileiros de endocrinologia e metabologia
Tânia L MazzucoO Chabre

Abstract

Cushing's syndrome due to ACTH-independent macronodular adrenal hyperplasia (AIMAH) can be associated with abnormal responses of aberrantly expressed adrenocortical receptors. This study aimed to characterize in vitro the pathophysiology of hypercortisolism in a beta-blocker-sensitive Cushing's syndrome due to AIMAH. Cortisol secretion profile under aberrant receptors stimulation revealed hyperresponsiveness to salbutamol (beta2-adrenoceptor agonist), cisapride (5-HT4 receptor agonist), and vasopressin in AIMAH cultured cells, but not in normal adrenocortical cells. By RT-PCR, AIMAH tissues revealed beta2-adrenoceptor overexpression rather than ectopical expression. MC2R expression was similar in both AIMAH and normal adrenocortical tissues. Curiously, cortisol levels of AIMAH cells under basal condition were 15-fold higher than those of control cells and were not responsive to ACTH. Analysis of culture medium from AIMAH cells could detect the presence of ACTH, which was immunohistochemically confirmed. Finally, the present study of AIMAH cells has identified: a) cortisol hyperresponsiveness to catecholamines, 5-HT4 and vasopressin in vitro, in agreement with clinical screening tests; b) abnormal expression of beta2-adrenocepto...Continue Reading

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Citations

Nov 29, 2013·The New England Journal of Medicine·Estelle LouisetHervé Lefebvre
Dec 5, 2014·The Journal of Endocrinology·Maria Candida Barisson Villares FragosoAndré Lacroix
May 15, 2015·European Journal of Endocrinology·Nada El GhorayebAndré Lacroix
Jun 7, 2014·The Journal of Clinical Endocrinology and Metabolism·Lucia GagliardiHamish S Scott
Oct 10, 2015·The Journal of Clinical Endocrinology and Metabolism·Emmanuelle DebillonOlivier Chabre
Apr 18, 2014·Current Opinion in Endocrinology, Diabetes, and Obesity·Agostino De VenanziAndré Lacroix

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