PMID: 8979814Jan 1, 1996Paper

Cellular and molecular correlates to plasticity during recovery from injury in the developing mammalian brain

Progress in Brain Research
C F IdeA Jelaso

Abstract

In summary, our studies indicate that the perinatal mammalian brain shows considerable plasticity in response to trauma. Studies carried out both in vivo in the perinatal mouse brain and in vitro in cell line culture and organotypic slice cultures of developing brain tissue, indicate that the cytokine, interleukin-1 beta (IL-1 beta) regulates early healing responses that restore the integrity of the damaged structure and create conditions conducive to the sprouting of new connections involved in plasticity. In response to a lesion placed in the cerebral cortex in a late third trimester embryo, astrocytes form a line that delimits damaged tissue being removed by phagocytic macrophages from tissue that will remain part of the neural parenchyma. By six days after birth, this line of delimiting astrocytes (LDA) appears to become the new glial limiting membrane or glial limitans at the lesion site. A gliotic scar covers the new glial limitans, but no gliosis appears within the neural parenchyma itself. The expression of IL-1 beta is upregulated in astrocytes that form the LDA and is also upregulated in the parenchyma internal to the LDA. Experiments done in vivo where the type 1 interleukin-1 receptor was blocked via injection of in...Continue Reading

Citations

Jun 22, 1999·Journal of Neuroscience Research·M Czapiga, C A Colton
May 2, 2001·Nature Reviews. Neuroscience·M A Dyer, C L Cepko
Dec 11, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·I PitaC F Ide
Aug 19, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D B StanimirovicA Muruganandam
Jun 5, 2001·Current Opinion in Pediatrics·H Kirpalani, E Asztalos
Feb 10, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Anna Jelaso LangerveldCharles F Ide
Aug 28, 2010·International Journal of Alzheimer's Disease·Erik HjorthMarianne Schultzberg
Oct 24, 2014·Frontiers in Pediatrics·Jason M RosenzweigIrina Burd
Aug 26, 1998·Stroke; a Journal of Cerebral Circulation·J A EllisonG Z Feuerstein
Jul 16, 2011·Developmental Neuroscience·Melinda CzehAngela M Kaindl
Feb 11, 2000·Annals of the New York Academy of Sciences·J A EllisonG Z Feuerstein
May 29, 1998·Progress in Neurobiology·H Aldskogius, E N Kozlova
Jun 26, 2009·Progress in Neurobiology·Laura LossiAdalberto Merighi
Mar 13, 1999·Science·D H Lowenstein, J M Parent

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