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Cellular and molecular determinants of cisplatin resistance

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)

Jan 20, 1999

R P Perez

Abstract

Cisplatin and carboplatin are among the most active and widely used cytotoxic anticancer drugs. However, the acquisition or presence of resistance significantly undermines the curative potential of these drugs against many malignancies. Multiple potential mechanisms of resistance have b...read more

Mentioned in this Paper

Biochemical Pathway
Antineoplastic Agents
Antibiotic Resistance, Neoplasm
Mismatch Repair
Base Excision Repair
Sulfhydryl Compounds
DNA, Neoplasm
Apoptosis
Malignant Neoplasms
DNA Damage
95
Paper Details
References
  • References61
  • Citations130
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  • References61
  • Citations130
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Cellular and molecular determinants of cisplatin resistance

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)

Jan 20, 1999

R P Perez

PMID: 9893624

DOI: 10.1016/s0959-8049(98)00227-5

Abstract

Cisplatin and carboplatin are among the most active and widely used cytotoxic anticancer drugs. However, the acquisition or presence of resistance significantly undermines the curative potential of these drugs against many malignancies. Multiple potential mechanisms of resistance have b...read more

Mentioned in this Paper

Biochemical Pathway
Antineoplastic Agents
Antibiotic Resistance, Neoplasm
Mismatch Repair
Base Excision Repair
Sulfhydryl Compounds
DNA, Neoplasm
Apoptosis
Malignant Neoplasms
DNA Damage
95

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DNA Damage

Cells are subjected to several DNA damaging events on a daily basis which results in the induction of DNA damage signaling and repair cascades to ensure genomic stability. Here is the latest research pertaining to DNA damage.

DNA Repair

DNA repair is critical to prevent detrimental mutations and maintain genomic stability that can otherwise lead to disease and disability. There are a number of different mechanisms of repair including base excision repair, direct repair, nucleotide excision repair and double-strand break repair. Discover the latest research on DNA repair here.

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Anti-cancer Drugs

Cisplatin resistance and oncogenes--a review

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W DempkeH J Schmoll
British Medical Journal

Adjuvant chemotherapy for early breast cancer

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Paper Details
References
  • References61
  • Citations130
12345...
  • References61
  • Citations130
12345...
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