Cellular and molecular effects of developmental exposure to diethylstilbestrol: implications for other environmental estrogens

Environmental Health Perspectives
R R Newbold

Abstract

Concerns have been raised regarding the role of environmental and dietary estrogens as possible contributors to an increased incidence of various abnormalities in estrogen-target tissues of both sexes. These abnormalities include breast cancer, endometriosis, fibroids, and uterine adenocarcinoma in females, as well as alterations in sex differentiation, decreased sperm concentrations, benign prostatic hyperplasia, prostatic cancer, testicular cancer, and reproductive problems in males. Whether these concerns are valid remains to be determined; however, studies with the potent synthetic estrogen diethylstilbestrol (DES) suggest that exogenous estrogen exposure during critical stages of development can result in permanent cellular and molecular alterations in the exposed organism. These alterations manifest themselves in the female and male as structural, functional, or long-term pathological changes including neoplasia. Although DES has potent estrogenic activity, it may be used as a model compound to study the effects of weaker environmental estrogens, many of which may fit into the category of endocrine disruptors.

References

Jan 1, 1977·Obstetrics and Gynecology·M BibboG L Wied
Jan 1, 1987·Teratogenesis, Carcinogenesis, and Mutagenesis·R R NewboldJ A McLachlan
Mar 1, 1985·Biochemical Pharmacology·R MaydlM Metzler
Jul 1, 1973·Obstetrics and Gynecology·W Pomerance
Sep 1, 1982·Fertility and Sterility·J A McLachlanR L Dixon
Oct 1, 1995·Environmental Health Perspectives·C Teng
Oct 1, 1995·Environmental Health Perspectives·J Gorski, Q Hou

❮ Previous
Next ❯

Citations

Nov 26, 2013·Steroids·Cheryl S WatsonAdriana A Paulucci-Holthauzen
Nov 26, 2013·Neurotoxicology and Teratology·Sofiane BoudaliaMarie-Chantal Canivenc-Lavier
Jan 12, 2010·Cellular and Molecular Life Sciences : CMLS·Albane le MairePatrick Balaguer
Mar 6, 2010·Cancer Causes & Control : CCC·Janneke VerloopMatti A Rookus
Aug 29, 1998·Environmental Health Perspectives·R BolgerW Checovich
Dec 23, 1998·Environmental Health Perspectives·D O CarpenterD D Vakharia
Jul 28, 1999·Environmental Health Perspectives·R BigsbyF S vom Saal
Jul 28, 1999·Environmental Health Perspectives·G R CunhaW Welshons
Jun 15, 2000·Environmental Health Perspectives·J L PryorB Robaire
Jun 16, 2000·Environmental Health Perspectives·S H Safe
Oct 26, 2000·Environmental Health Perspectives·E M UlrichR M Bigsby
Jun 27, 2003·Environmental Health Perspectives·Wade V WelshonsFrederick S vom Saal
Jun 27, 2003·Environmental Health Perspectives·Gordon P FlakeDarlene Dixon
Feb 9, 2002·Environmental Health Perspectives·David O CarpenterDavid C Spink
May 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Barry G TimmsFrederick S vom Saal
Jul 5, 2006·Environmental Health Perspectives·Ioanna KatsiadakiAlexander Pickering Scott
Jun 9, 2009·Endocrine Reviews·Evanthia Diamanti-KandarakisAndrea C Gore
Sep 25, 2012·Asian Journal of Andrology·Stephen Safe
Mar 14, 2001·Journal of Experimental Marine Biology and Ecology·Z BillinghurstM H. Depledge
Aug 2, 2001·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J L SpearowM Barkley
Dec 15, 2000·International Journal of Andrology·G H BehrensT B Haugen
Jul 28, 2007·Reviews in Endocrine & Metabolic Disorders·Felix Grün, Bruce Blumberg
Jan 22, 1998·Mutation Research·J B BishopR A Sloane
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·N Ben-Jonathan, R Steinmetz
Jul 4, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Giuseppe Benagiano, Ivo Brosens
Apr 29, 1998·Critical Reviews in Toxicology·R J GoldenE A Reese
Jan 9, 2016·Clinical Obstetrics and Gynecology·Lauren A Wise, Shannon K Laughlin-Tommaso
Jan 31, 2016·Reviews in Endocrine & Metabolic Disorders·Eleni Palioura, Evanthia Diamanti-Kandarakis
Nov 1, 2012·Annales d'endocrinologie·A S NassouriR Desailloud
Oct 28, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Camilla AlexandersonAgneta Holmäng
Apr 28, 2009·Mutation Research·Prashantha Naik, K K Vijayalaxmi
Jun 17, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Retha R NewboldWendy N Jefferson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.