Cellular and molecular features of neurogenic skeletal muscle atrophy.

Experimental Neurology
Jeffrey T Ehmsen, Ahmet Höke

Abstract

Neurogenic atrophy refers to the loss of muscle mass and function that results directly from injury or disease of the peripheral nervous system. Individuals with neurogenic atrophy may experience reduced functional status and quality of life and, in some circumstances, reduced survival. Distinct pathological findings on muscle histology can aid in diagnosis of a neurogenic cause for muscle dysfunction, and provide indicators for the chronicity of denervation. Denervation induces pleiotypic responses in skeletal muscle, and the molecular mechanisms underlying neurogenic muscle atrophy appear to share common features with other causes of muscle atrophy, including activation of FOXO transcription factors and corresponding induction of ubiquitin-proteasomal and lysosomal degradation. In this review, we provide an overview of histologic features of neurogenic atrophy and a summary of current understanding of underlying mechanisms.

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Citations

Dec 22, 2020·Frontiers in Physiology·Junxi DaiJianguang Xu
Nov 6, 2020·International Journal of Molecular Sciences·Ian R D JohnsonDaniela Grimm
Jul 13, 2021·Frontiers in Bioengineering and Biotechnology·Benjamin R SlavinSami H Tuffaha
Aug 7, 2021·Journal of Personalized Medicine·Oihane Pikatza-MenoioSonia Alonso-Martín

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