PMID: 11915911Mar 28, 2002Paper

Cellular and molecular mechanisms for the bone response to mechanical loading

International Journal of Sport Nutrition and Exercise Metabolism
S A Bloomfield

Abstract

To define the cellular and molecular mechanisms for the osteogenic response of bone to increased loading, several key steps must be defined: sensing of the mechanical signal by cells in bone, transduction of the mechanical signal to a biochemical one, and transmission of that biochemical signal to effector cells. Osteocytes are likely to serve as sensors of loading, probably via interstitial fluid flow produced during loading. Evidence is presented for the role of integrins, the cell's actin cytoskeleton, G proteins, and various intracellular signaling pathways in transducing that mechanical signal to a biochemical one. Nitric oxide, prostaglandins, and insulin-like growth factors all play important roles in these pathways. There is growing evidence for modulation of these mechanotransduction steps by endocrine factors, particularly parathyroid hormone and estrogen. The efficiency of this process is also impaired in the aged animal, yet what remains undefined is at what step mechanotransduction is affected.

Citations

Jan 6, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Giridhar M ShivaramChristopher R Jacobs
Apr 26, 2019·Investigative Ophthalmology & Visual Science·Muhammad Zain ChauhanSanjoy K Bhattacharya
Feb 9, 2005·The Journal of Craniofacial Surgery·Cory S GoldbergJeffrey A Fialkov
Nov 4, 2006·Biomechanics and Modeling in Mechanobiology·Lindsay M GodinSeth W Donahue
Apr 25, 2008·Journal of Dental Research·G E Wise, G J King
Jan 24, 2014·Acta ortopedica brasileira·Fernando Tadeu Trevisan FrajacomoSérgio Britto Garcia
Sep 1, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Jill M SladeGary A Dudley
Mar 3, 2009·Journal of Aging and Health·Danilo Sales BocaliniRozeli Ferreira Levy

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