Cellular and molecular mechanisms of cyclosporin nephrotoxicity.

Journal of the American Society of Nephrology : JASN
J B Kopp, P E Klotman

Abstract

Cyclosporin therapy is associated with several forms of nephrotoxicity, the most significant of which are reversible impairment of glomerular filtration and irreversible interstitial fibrosis. Impaired glomerular filtration is due to both reduction in Kf, the glomerular capillary ultrafiltration coefficient, and to reduction in renal blood flow. The mechanisms responsible for the low Kf are not well defined, but heightened mesangial cell contractility may contribute. Reduced renal blood flow with chronic cyclosporin therapy arises from both endothelial damage and altered eicosanoid metabolism, in particular increased thromboxane synthesis. Renal interstitial fibrosis, which develops in some patients after approximately 6-12 months of cyclosporin therapy, poses a major limitation to the chronic use of the drug. Two mechanisms likely contribute to cyclosporin-associated interstitial fibrosis. First, endothelial injury and vasoconstriction produce renal ischemia, which in turn is associated with enhanced synthesis of extracellular matrix proteins. Second, cyclosporin likely influences the accumulation of matrix proteins in the renal interstitium through nonhemodynamic mechanisms, as suggested by altered matrix accumulation in non-...Continue Reading

Citations

Apr 27, 1999·Therapeutic Drug Monitoring·R E Dupuis, E S Sredzienski
Nov 26, 2003·Journal of the American Society of Nephrology : JASN·Pilar JustoAlberto Ortiz
Jan 16, 1999·Journal of the American Society of Nephrology : JASN·M VerbekeN Lameire
Sep 27, 2000·Journal of the American Society of Nephrology : JASN·Huong T B TranEdgar L Milford
Jan 3, 2001·Transplantation Proceedings·J SantosS Guimarães
May 4, 2001·European Journal of Pharmacology·J Liu, L J Brunner
Apr 1, 1999·Annual Review of Physiology·T Miyauchi, T Masaki
Aug 31, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Madhura PradhanKathy L Jabs
Sep 15, 1998·Kidney International. Supplement·M VerbekeN Lameire
Dec 5, 1998·Kidney International. Supplement·A OrtizJ Egido
Aug 15, 2002·Transplantation Proceedings·Barbara SuwelackH Hohage
Dec 11, 2002·Kidney International·Iris FeriaNorma A Bobadilla
Apr 3, 2003·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Marianne PonsDenis Beauchamp
Nov 13, 2002·Kidney International·Chien-Te LeeYeong-Hau H Lien
Apr 15, 2003·Journal of the American College of Surgeons·Chumpon WilasrusmeeDilip S Kittur
Nov 12, 2003·Pharmacology & Therapeutics·Farzad Moien-AfshariIsmail Laher
May 25, 2002·Heart Disease·Nishan AsharyElizabeth A M M Frost
Mar 6, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·José-Antonio GómezJuan-R Malagelada
Feb 6, 1998·The Journal of Laboratory and Clinical Medicine·T ParraM Rodriguez-Puyol
Sep 4, 1999·Anesthesia and Analgesia·G KostopanagiotouJ Papadimitriou
Jun 1, 1992·Seminars in Arthritis and Rheumatism·D J Cohen, G B Appel
Oct 21, 2000·Hypertension·L G Sánchez-LozadaN A Bobadilla
Apr 28, 2005·The Journal of Surgical Research·Nicholas R BrookMichael L Nicholson
Mar 18, 2005·Journal of the American Society of Nephrology : JASN·Ingeborg A HauserMatthias Schwab
Apr 1, 2003·Expert Opinion on Investigational Drugs·Jens W Eckstein, John Fung
Jun 28, 2005·Life Sciences·Isabelle DubusChristian Combe
Oct 17, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Stacy L McClureKenneth B Gordon
Jul 27, 2001·Neurologic Clinics·D S Younger, N Raksadawan
Jul 30, 2021·Immunity, Inflammation and Disease·Susanne V FleigSibylle von Vietinghoff
Jul 5, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jun FujishiroEiji Kobayashi
Jul 13, 2006·American Journal of Physiology. Renal Physiology·Jazmin Pérez-RojasNorma A Bobadilla
Jun 1, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Aisling O'RiordanAlan J Watson
Jan 30, 2007·Nephron. Experimental Nephrology·Donata CibulskyteJens Mortensen
Jun 30, 1994·Annals of the New York Academy of Sciences·Z GreenfeldS Pisanty

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Diabetes and Its Complications
P A CravenF R DeRubertis
Journal of the American Society of Nephrology : JASN
W F KeaneP G Schmitz
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
R ZietseW Weimar
© 2021 Meta ULC. All rights reserved