PMID: 9440546Jan 24, 1998Paper

Cellular and molecular mechanisms of IL-5 synthesis in atopic diseases: a study with allergen-specific human helper T cells

The Journal of Allergy and Clinical Immunology
A MoriH Okudaira

Abstract

Cytokines produced by helper T cells are intimately involved in chronic allergic diseases associated with eosinophilic inflammation. We investigated the production of IL-5, a potent growth factor and chemotactic factor for eosinophils, by CD4+ T lymphocytes in patients with asthma. Allergen-specific T cell clones and T cell hybridomas were established from the peripheral blood lymphocytes of patients with asthma, and the responses to various stimuli were determined. After nonspecific stimulation, IL-5 production by CD4+ T cells from both atopic and nonatopic subjects with asthma was significantly enhanced compared with that by cells from healthy controls. Peripheral blood mononuclear cells from atopic asthma patients both proliferated and produced IL-5 after incubation with mite allergen, suggesting that mite-specific helper T cells were involved in the eosinophilic inflammation of atopic asthma. A human IL-5 promoter/enhancer luciferase gene construct transfected into IL-5-producing T cell clones was clearly transcribed after stimulation, indicating that the 515 base pair IL-5 gene segment upstream of the coding region was sufficient to respond to activating signals in human helper T cells. The same gene segment was not transc...Continue Reading

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Citations

Nov 28, 2002·Clinical and Experimental Immunology·K OgawaA Mori
Jun 25, 2008·International Archives of Allergy and Immunology·Noriko KitamuraAkio Mori
Apr 3, 2007·American Journal of Respiratory and Critical Care Medicine·Pierre CamaterosDanuta Radzioch
May 11, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K OgawaA Mori
Nov 4, 2000·Expert Opinion on Investigational Drugs·J K Weltman, A S Karim
Nov 6, 2012·Progress in Lipid Research·Alexandra C Kendall, Anna Nicolaou
Feb 5, 2013·The Journal of Allergy and Clinical Immunology·Lynda SchneiderDana Wallace
Apr 8, 2014·Annales de dermatologie et de vénéréologie·S RoncerayC Droitcourt
Jun 6, 2006·The Journal of Allergy and Clinical Immunology·Noriaki AoiYasunobu Yoshikai
Feb 5, 2013·The Journal of Allergy and Clinical Immunology·Maeve A McAleer, Alan D Irvine
Sep 1, 2006·Expert Review of Clinical Immunology·Osamu KaminumaAkio Mori
Aug 21, 2001·Rheumatology·M AringerW B Graninger
Jun 11, 2005·International Archives of Allergy and Immunology·Tomomi HashimotoAkio Mori
Jun 11, 2005·International Archives of Allergy and Immunology·Osamu KaminumaShoichiro Miyatake
Jun 1, 2012·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kazuko YamaokaTakachika Hiroi
Oct 25, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E SimmsM Larché
Oct 22, 2019·The Journal of Dermatological Treatment·Michael J CorkGraham S Ogg

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