Abstract
We investigated the cellular and molecular mechanisms of systolic and diastolic dysfunction in a furazolidone (Fz)-induced model of dilated cardiomyopathy (DCM) in turkey poults. Serial echocardiograms disclosed marked systolic dysfunction in the Fz-treated poults, and ventricular weight and left ventricular (LV)/body weight ratio were significantly increased. Isolated heart experiments were performed to determine LV pressure-volume (P-V) relationships. In addition, LV sarcomere lengths (SLs) were measured after hearts had been fixed, and wall stress (sigma)-SL relationships were determined. When compared to control hearts, LV chamber volume in DCM hearts was approximately 3-fold increased, the active or developed LV P-V relationship was markedly depressed, the passive or diastolic P-V relationship was steeper, and SLs were significantly shorter. However, the developed sigma-SL relationships of DCM and control hearts were not different indicating that intrinsic myocardial capacity to generate active force is unaffected in this model of DCM. In contrast, passive sigma, and passive tension in trabecular muscle preparations increased much more steeply with SL in DCM than normal hearts. Trabecular muscle experiments disclosed that ...Continue Reading
Citations
Feb 4, 2010·Circulation·Martin M LewinterHenk Granzier
Oct 8, 2011·PloS One·Xian-Liang TangRoberto Bolli
Jul 3, 2013·PloS One·Ming ZhangRui Yan
Jul 1, 2009·The Journal of Physiological Sciences : JPS·Adolfo Virgen-OrtizJ Muñiz
Aug 23, 2005·American Journal of Veterinary Research·Mark A Oyama, Sridar Chittur
Dec 3, 2014·Journal of Molecular and Cellular Cardiology·Kirk R HutchinsonHenk Granzier
Nov 19, 2015·Radiation Research·KunYi ZhangXiuren Gao
Oct 23, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Cong LeiYi Zhu
Apr 24, 2008·European Journal of Pharmacology·Yuansheng ZhaiZhiyi Zuo
Aug 18, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Xiaodong LiLinghui Zhao
Apr 17, 2007·Animal Genetics·K M ReedD L Kooyman
Apr 25, 2006·Immunology·Razi Khan, Richard Sheppard
Jul 17, 2012·Journal of Molecular and Cellular Cardiology·Yiming WuMark E Anderson
Aug 14, 2010·Journal of Molecular and Cellular Cardiology·Shannamar DeweyAldrin Gomes
Apr 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gaohong Wu, Shi-Jiang Li
Apr 24, 2010·Journal of Neurochemistry·Ioannis DafnisAngeliki Chroni
Aug 30, 2008·The FEBS Journal·Iordanes KaragiannidesKyriakos E Kypreos
Jul 12, 2011·The FEBS Journal·Eleni A KaraviaKyriakos E Kypreos
Nov 3, 2011·PloS One·Marine DouaudFrédérique Pitel
Jun 13, 2019·Angiology·Eva XepapadakiKyriakos E Kypreos
Apr 29, 2006·Journal of Cardiovascular Medicine·Paolo FerrazziEugenio Quaini
Sep 13, 2007·Molecular and Cellular Biochemistry·P SivakumarSubha Sen
Dec 15, 2020·Life Sciences·Savalan Babapoor-FarrokhranSumeet K Mainigi
May 22, 2008·Poultry Science·K M MendozaK M Reed
Jun 17, 2008·The Journal of Experimental Biology·Holly A Shiels, Ed White