Cellular and Molecular Mechanisms Underlying Arterial Baroreceptor Remodeling in Cardiovascular Diseases and Diabetes

Neuroscience Bulletin
Huiyin TuYu-Long Li

Abstract

Clinical trials and animal experimental studies have demonstrated an association of arterial baroreflex impairment with the prognosis and mortality of cardiovascular diseases and diabetes. As a primary part of the arterial baroreflex arc, the pressure sensitivity of arterial baroreceptors is blunted and involved in arterial baroreflex dysfunction in cardiovascular diseases and diabetes. Changes in the arterial vascular walls, mechanosensitive ion channels, and voltage-gated ion channels contribute to the attenuation of arterial baroreceptor sensitivity. Some endogenous substances (such as angiotensin II and superoxide anion) can modulate these morphological and functional alterations through intracellular signaling pathways in impaired arterial baroreceptors. Arterial baroreceptors can be considered as a potential therapeutic target to improve the prognosis of patients with cardiovascular diseases and diabetes.

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Citations

Jan 20, 2019·Neuroscience Bulletin·Zixi Jack ChengQing-Hui Chen
Dec 10, 2020·Cellular Signalling·Fang PeiZhihe Zhao
Apr 27, 2021·Frontiers in Neuroscience·Maurizio AcampaTijana Bojić

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Methods Mentioned

BETA
transgenic
transfection

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