Cellular and molecular neuropathology of schizophrenia: new directions from developmental neurobiology

Schizophrenia Research
E E TurnerD V Jeste

Abstract

Schizophrenia is in essence a developmental disorder, but an unusual one in that the onset of symptoms is markedly delayed. Neuropathologic studies of the brain in schizophrenia have revealed subtle abnormalities that may reflect abnormal neuronal development. A more detailed examination of the cellular and molecular pathology of schizophrenia has been limited by the lack of informative markers that might allow a more complete understanding of the brain defects that characterize this disorder. Recent advances in molecular biology have made available a growing number of probes for examining the expression of specific gene products in brain tissue by using in situ hybridization and immunohistochemistry using antibodies to recombinant antigens. Several recently cloned neural genes are expressed in the forebrain regions which have been implicated in schizophrenia, and may have significant roles in brain development or function. Selected neurotransmitter receptors, neurotrophins and their receptors, and transcription factors of the POU and MADS families are promising candidates for future studies of the cellular and molecular neuropathology of schizophrenia.

References

Sep 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·T J Crow, D J Done
Dec 1, 1992·Archives of General Psychiatry·E S Susser, S P Lin
Nov 20, 1992·Brain Research. Developmental Brain Research·G W HuntleyP J Isackson
Oct 1, 1992·The American Journal of Psychiatry·H S BrachaC Cunniff
Jan 1, 1992·Acta Psychiatrica Scandinavica·S OnstadE Kringlen
Mar 1, 1992·Archives of General Psychiatry·R B ZipurskyA Pfefferbaum
May 25, 1991·Lancet·E O'CallaghanR M Murray
Jan 1, 1991·Schizophrenia Bulletin·F M BenesE D Bird
Apr 1, 1991·The American Journal of Psychiatry·E O'CallaghanJ L Waddington
Jan 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·G W Roberts
May 1, 1991·Archives of General Psychiatry·A J ConradA B Scheibel
Jul 1, 1991·Archives of General Psychiatry·S E ArnoldA R Damasio
May 1, 1990·Psychological Medicine·C J BrutonG W Roberts
Jan 1, 1989·Schizophrenia Bulletin·F M Benes
Jan 1, 1989·Schizophrenia Bulletin·M F GreenF Kharabi
Nov 1, 1989·Archives of General Psychiatry·D V Jeste, J B Lohr
Jun 1, 1988·Developmental Medicine and Child Neurology·R Goodman
Sep 1, 1988·Biological Psychiatry·P FalkaiM Rozumek
Nov 1, 1988·Acta Psychiatrica Scandinavica·A VitaC L Cazzullo
Jan 1, 1987·Journal of Psychiatric Research·S W Lewis, R M Murray
Feb 1, 1988·Archives of General Psychiatry·S A MednickD Bonett
Jul 1, 1987·Archives of General Psychiatry·F M Benes, E D Bird
Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
Jan 1, 1986·Journal of Neural Transmission·H Jakob, H Beckmann
Jan 1, 1986·European Archives of Psychiatry and Neurological Sciences·P Falkai, B Bogerts
Jan 1, 1986·Archives of General Psychiatry·F M BenesE D Bird
Jan 1, 1983·Schizophrenia Bulletin·J D GuyM P Guy
Jan 1, 1995·Annual Review of Medicine·K J Kotrla, D R Weinberger
Apr 1, 1995·Current Opinion in Cell Biology·M Barbacid
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D LeiferS A Lipton
May 1, 1995·The American Journal of Psychiatry·D V JesteR Heaton
Apr 3, 1995·Brain Research·P W BurnetP J Harrison
Jan 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·A M Sierra-HonigmannR H Yolken

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Citations

Jun 18, 2005·Brain Research. Molecular Brain Research·Andrew J GrottickYaron Hakak
Jun 19, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Marcel E MoranNitin Gogtay
Aug 5, 2003·Perspectives in Psychiatric Care·Lora Humphrey Beebe
Jun 8, 2001·Neuron·N A BerminghamH Y Zoghbi

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