Cellular and physiological circadian mechanisms drive diurnal cell proliferation and expansion of white adipose tissue.

Nature Communications
Aleix Ribas-LatreKristin L Eckel-Mahan

Abstract

Hyperplastic expansion of white adipose tissue (WAT) relies in part on the proliferation of adipocyte precursor cells residing in the stromal vascular cell fraction (SVF) of WAT. This study reveals a circadian clock- and feeding-induced diurnal pattern of cell proliferation in the SVF of visceral and subcutaneous WAT in vivo, with higher proliferation of visceral adipocyte progenitor cells subsequent to feeding in lean mice. Fasting or loss of rhythmic feeding eliminates this diurnal proliferation, while high fat feeding or genetic disruption of the molecular circadian clock modifies the temporal expression of proliferation genes and impinges on diurnal SVF proliferation in eWAT. Surprisingly, high fat diet reversal, sufficient to reverse elevated SVF proliferation in eWAT, was insufficient in restoring diurnal patterns of SVF proliferation, suggesting that high fat diet induces a sustained disruption of the adipose circadian clock. In conclusion, the circadian clock and feeding simultaneously impart dynamic, regulatory control of adipocyte progenitor proliferation, which may be a critical determinant of adipose tissue expansion and health over time.

References

Jan 1, 1986·Differentiation; Research in Biological Diversity·H SugiharaK Yun
Sep 1, 1968·The Journal of Clinical Investigation·Y TakahashiW H Daughaday
Jun 6, 2000·Experimental Cell Research·E Endl, J Gerdes
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·D B HausmanR J Martin
Aug 28, 2004·Endocrinology·Maofu FuRichard G Pestell
Apr 23, 2005·Science·Fred W TurekJoseph Bass
Aug 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Shigeki ShimbaMasakatsu Tezuka
Nov 8, 2005·Cell Metabolism·Atsushi IshidaHitoshi Okamura
Mar 29, 2006·Diabetes·Sanjin ZvonicJeffrey M Gimble
May 6, 2006·Neuron·Jason P DebruyneSteven M Reppert
Feb 23, 2007·Annual Review of Nutrition·Robin E DuncanHei Sook Sul
Apr 10, 2007·Nature Neuroscience·Jason P DeBruyneSteven M Reppert
Jul 20, 2007·Current Biology : CB·Jason P DeBruyneSteven M Reppert
Nov 7, 2007·Cell Metabolism·Akira KohsakaJoseph Bass
Feb 8, 2008·Nature·Simón Méndez-FerrerPaul S Frenette
Sep 20, 2008·Science·Wei TangJonathan M Graff
Oct 7, 2008·Cell·Matthew S RodehefferJeffrey M Friedman
Mar 28, 2009·PLoS Computational Biology·Junghyo JoVipul Periwal
May 30, 2009·Obesity·Cecilia Gómez-SantosMarta Garaulet
Nov 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Christopher VollmersSatchidananda Panda
May 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Masanobu KawaiClifford J Rosen
Sep 30, 2010·Journal of Biological Rhythms·Michael E HughesKarl Kornacker
Nov 3, 2010·Cell Metabolism·Benedetto GrimaldiPaolo Sassone-Corsi
Jun 3, 2011·The Journal of Clinical Investigation·Kai SunPhilipp E Scherer
Mar 21, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kristin L Eckel-MahanPaolo Sassone-Corsi
May 23, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bingyan GuoKe Ma
Nov 13, 2012·Nature Medicine·Georgios K PaschosGarret A Fitzgerald
Jan 22, 2013·The European Journal of Neuroscience·Julie S PendergastShin Yamazaki
Feb 26, 2013·Diabetes·Anton ShostakHenrik Oster
May 28, 2013·Cell·María Casanova-AcebesAndrés Hidalgo
Sep 10, 2013·Cell Metabolism·Yun-Hee LeeJames G Granneman
Dec 24, 2013·Cell·Kristin L Eckel-MahanPaolo Sassone-Corsi
May 28, 2014·Nature Reviews. Endocrinology·Karen L GambleMartin E Young
Jun 25, 2014·Proceedings of the National Academy of Sciences of the United States of America·Céline FeilletDavid A Rand
Oct 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ray ZhangJohn B Hogenesch
Sep 1, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Alexes C DaquinagMikhail G Kolonin
Dec 9, 2015·The Journal of Biological Chemistry·Serena AbbondantePaolo Sassone-Corsi
Jun 21, 2016·Cell Metabolism·Elise JefferyMatthew S Rodeheffer

❮ Previous
Next ❯

Methods Mentioned

BETA
cell
RNA-seq
gastric bypass
fluorescence activated cell sorting
fluorescence
biopsies

Software Mentioned

cosinor
ImageJ
Actimetrics
JTK
Adiposoft
- Fiji
R studio
Cycle
FlowJo
cosinor2

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.